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PF299804 (Dacomitinib, PF299)

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EGFR inhibitor

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Catalog No. A11051

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF299804 5mg A11051-5

Regular Price: $90.00

Special Price: $81.00

PF299804 10mg A11051-10

Regular Price: $160.00

Special Price: $144.00

PF299804 50mg A11051-50

Regular Price: $450.00

Special Price: $405.00

PF299804 100mg A11051-100

Regular Price: $750.00

Special Price: $675.00

PF299804 10mM * 1mL in DMSO A11051-10mM-D

Regular Price: $144.00

Special Price: $129.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.

PF299804 (Dacomitinib, PF299)

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Publications citing Adooq Products
PF299804 (Dacomitinib, PF299) Citations (3)
  • Momeny M, .et al. The ERBB receptor inhibitor dacomitinib suppresses proliferation and invasion of pancreatic ductal adenocarcinoma cells, Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
  • Majid Momeny, .et al. Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells, Sci Rep, 2017, 7: 4204 PMID: 28646172
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Chemical Information

Catalog Num A11051
Actions Inhibitor
M. Wt 469.9
Formula C24H25ClFN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1110813-31-4
Synonyms PF-299804, Dacomitinib, PF-299
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4

Biological Activity

Description
 PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.
Targets
EGFR (Cell-free assay) ErbB2 (Cell-free assay) ErbB4 (Cell-free assay)
6.0 nM45.7 nM73.7 nM

Solubility

Solubility (25°C) * In vitro DMSO 19 mg/mL (40.43 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.28 mL 106.41 mL 212.81mL
0.5 mM 4.26 mL 21.28 mL 42.56 mL
1 mM 2.13 mL 10.64 mL 21.28 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
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A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
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A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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