PF299804 (Dacomitinib, PF299)

PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.
Grouped product items
Product Name Price Stock Qty
PF299804 5mg
In stock
PF299804 10mg
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PF299804 50mg
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PF299804 100mg
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PF299804 10mM * 1mL in DMSO
In stock

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's PF299804 (Dacomitinib, PF299) has been cited by 5 publications
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Momeny M, .et al. , Cell Oncol (Dordr), 2019, Apr 25 PMID: 31025257
  • Majid Momeny, .et al. , Sci Rep, 2017, 7: 4204 PMID: 28646172
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Biological Activity
    Discription PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4.
    Target Value
    Chemical Information
    Catalog Num A11051
    Formula C24H25ClFN5O2
    Molecular Weight 469.9
    CAS Number 1110813-31-4
    Synonyms PF-299804, Dacomitinib, PF-299

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 17 mg/mL (36.17 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80, pH 9 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.28 mL 106.41 mL 212.81 mL
    0.5 mM 4.26 mL 21.28 mL 42.56 mL
    1 mM 2.13 mL 10.64 mL 21.28 mL
    5 mM 0.43 mL 2.13 mL 4.26 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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