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Publications citing Adooq Products
PF299804 (Dacomitinib, PF299) Citations (2)
- Majid Momeny,et al. Dacomitinib, a pan-inhibitor of ErbB receptors, suppresses growth and invasive capacity of chemoresistant ovarian carcinoma cells, Sci Rep, 2017, 7: 4204 28646172
- Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
Chemical Information
| Catalog Num | A11051 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 469.9 |
| Formula | C24H25ClFN5O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1110813-31-4 |
| Synonyms | PF-299804, Dacomitinib, PF-299 |
| SMILES code | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4 |
| Chemical Name | (E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enamide |
Description |
PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 19 mg/mL (40.43 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 1% DMSO/30% polyethylene glycol/1% Tween 80, pH 9 | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.28 mL | 106.41 mL | 212.81mL |
| 0.5 mM | 4.26 mL | 21.28 mL | 42.56 mL |
| 1 mM | 2.13 mL | 10.64 mL | 21.28 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.26 mL |
*The above data is based on the productmolecular weight 469.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10043 | AEE788 | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| A11022 | AG-1478 (Tyrphostin AG-1478) | <1 mg/mL | 25 mg/mL | 13 mg/mL |
| A10047 | AG 490 | <1 mg/mL | 59 mg/mL | 6 mg/mL |
| A11027 | ARRY-380 | <1 mg/mL | 114 mg/mL | <1 mg/mL |
| A11158 | ARRY334543 | <1 mg/mL | 6 mg/mL | <1 mg/mL |
| A11155 | AST-1306 | <1 mg/mL | 124 mg/mL | <1 mg/mL |
| A10116 | AZD8931 | <1 mg/mL | 40 mg/mL | <1 mg/mL |
| A11334 | BIBX 1382 | 50 mg/mL | 50 mg/mL | N/A |
| A11209 | Lenalidomide (CC-5013) | <1 mg/mL | 113 mg/mL | 20 mg/mL |
| A10743 | BMS 599626 (AC480) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A10211 | Canertinib (CI-1033) | <1 mg/mL | 2 mg/mL | 9 mg/mL |
| A10210 | Chrysophanic acid (Chrysophanol) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10242 | CP-724714 | <1 mg/mL | 94 mg/mL | 94 mg/mL |
| A10362 | Erlotinib hydrochloride | <1 mg/mL | 3 mg/mL | <1 mg/mL |
| A10422 | Gefitinib (Iressa) | <1 mg/mL | 89 mg/mL | 4 mg/mL |
| A10514 | Lapatinib Ditosylate | <1 mg/mL | 185 mg/mL | <1 mg/mL |
| A10612 | Mubritinib (TAK 165) | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10638 | Neratinib (HKI-272) | 2 mg/mL | <1 mg/mL | <1 mg/mL |
| A10678 | OSI-420 | 83 mg/mL | 2 mg/mL | <1 mg/mL |
| A10702 | PD153035 (HCl salt) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10706 | Pelitinib (EKB-569) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| A11051 | PF299804 | <1 mg/mL | 19 mg/mL | <1 mg/mL |
| A11236 | TAK-285 | <1 mg/mL | 110 mg/mL | 54 mg/mL |
| A10053 | Tyrphostin AG 879 | 36 mg/mLtd | <1 mg/mL | 3 mg/mL |
| A10990 | WZ3146 | <1 mg/mL | 93 mg/mL | <1 mg/mL |
| A10991 | WZ4002 | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10992 | WZ8040 | 96 mg/mL | <1 mg/mL | 3 mg/mL |
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