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AG-1478 (Tyrphostin AG-1478)

Catalog No.: A11022

EGFR Inhibitor

AG-1478 (Tyrphostin AG-1478)

AG-1478 (Tyrphostin AG-1478) Chemical Structure

CAS NO. 153436-53-4

AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.

Availability: In stock

Package Price Qty
5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
  • Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733

Biological Activity

AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
EGFR (Cell-free assay) HER2 (Cell-free assay) PDGFR (Cell-free assay)
3 nM>100 μM>100 μM
In vitro (25°C) DMSO 25 mg/mL (79.17 mM)
Water Insoluble
Ethanol 13 mg/mL (41.17 mM)
In vivo 15% Captisol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.67 mL 158.33 mL 316.66 mL
0.5 mM 6.33 mL 31.67 mL 63.33 mL
1 mM 3.17 mL 15.83 mL 31.67 mL
5 mM 0.63 mL 3.17 mL 6.33 mL

*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11022
Actions Inhibitor
CAS No. 153436-53-4
Formula C16H14ClN3O2
M. Wt 315.8
Purity >98%
Synonyms AG1478, AG 1478

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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