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Publications citing Adooq Products
AG-1478 (Tyrphostin AG-1478) Citations (2)
- Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733
Chemical Information
| Catalog Num | A11022 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 315.8 |
| Formula | C16H14ClN3O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 153436-53-4 |
| Synonyms | AG1478, AG 1478 |
| SMILES code | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| Chemical Name | N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinanine |
Description |
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 25 mg/mL (79.17 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 13 mg/mL (41.17 mM) | ||
| In vivo | 15% Captisol | 15% Captisol | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.67 mL | 158.33 mL | 316.66mL |
| 0.5 mM | 6.33 mL | 31.67 mL | 63.33 mL |
| 1 mM | 3.17 mL | 15.83 mL | 31.67 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10043 | AEE788 | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| A11022 | AG-1478 (Tyrphostin AG-1478) | <1 mg/mL | 25 mg/mL | 13 mg/mL |
| A10047 | AG 490 | <1 mg/mL | 59 mg/mL | 6 mg/mL |
| A11027 | ARRY-380 | <1 mg/mL | 114 mg/mL | <1 mg/mL |
| A11158 | ARRY334543 | <1 mg/mL | 6 mg/mL | <1 mg/mL |
| A11155 | AST-1306 | <1 mg/mL | 124 mg/mL | <1 mg/mL |
| A10116 | AZD8931 | <1 mg/mL | 40 mg/mL | <1 mg/mL |
| A11334 | BIBX 1382 | 50 mg/mL | 50 mg/mL | N/A |
| A11209 | Lenalidomide (CC-5013) | <1 mg/mL | 113 mg/mL | 20 mg/mL |
| A10743 | BMS 599626 (AC480) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A10211 | Canertinib (CI-1033) | <1 mg/mL | 2 mg/mL | 9 mg/mL |
| A10210 | Chrysophanic acid (Chrysophanol) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10242 | CP-724714 | <1 mg/mL | 94 mg/mL | 94 mg/mL |
| A10362 | Erlotinib hydrochloride | <1 mg/mL | 3 mg/mL | <1 mg/mL |
| A10422 | Gefitinib (Iressa) | <1 mg/mL | 89 mg/mL | 4 mg/mL |
| A10514 | Lapatinib Ditosylate | <1 mg/mL | 185 mg/mL | <1 mg/mL |
| A10612 | Mubritinib (TAK 165) | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10638 | Neratinib (HKI-272) | 2 mg/mL | <1 mg/mL | <1 mg/mL |
| A10678 | OSI-420 | 83 mg/mL | 2 mg/mL | <1 mg/mL |
| A10702 | PD153035 (HCl salt) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10706 | Pelitinib (EKB-569) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| A11051 | PF299804 | <1 mg/mL | 19 mg/mL | <1 mg/mL |
| A11236 | TAK-285 | <1 mg/mL | 110 mg/mL | 54 mg/mL |
| A10053 | Tyrphostin AG 879 | 36 mg/mLtd | <1 mg/mL | 3 mg/mL |
| A10990 | WZ3146 | <1 mg/mL | 93 mg/mL | <1 mg/mL |
| A10991 | WZ4002 | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10992 | WZ8040 | 96 mg/mL | <1 mg/mL | 3 mg/mL |
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