Total item
Cart Subtotal
$0.00 - Khattab M, .et al. Conformational Plasticity in Tyrosine Kinase Inhibitor-Kinase Interactions Revealed with Fluorescence Spectroscopy and Theoretical Calculations, J Phys Chem B, 2018, May 3;122(17):4667-4679 PMID: 29629773
- Muhammad Khattab, .et al. A pH-induced conformational switch in a tyrosine kinase inhibitor identified by electronic spectroscopy and quantum chemical calculations, Sci Rep, 2017, 7: 16271 PMID: 29176733
Biological Activity
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM.
Targets
| EGFR (Cell-free assay) | HER2 (Cell-free assay) | PDGFR (Cell-free assay) | ||
| 3 nM | >100 μM | >100 μM |
| In vitro (25°C) | DMSO | 25 mg/mL (79.17 mM) | |
| Water | Insoluble | ||
| Ethanol | 13 mg/mL (41.17 mM) | ||
| In vivo | 15% Captisol | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.67 mL | 158.33 mL | 316.66 mL |
| 0.5 mM | 6.33 mL | 31.67 mL | 63.33 mL |
| 1 mM | 3.17 mL | 15.83 mL | 31.67 mL |
| 5 mM | 0.63 mL | 3.17 mL | 6.33 mL |
*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11022 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 153436-53-4 |
| Formula | C16H14ClN3O2 |
| M. Wt | 315.8 |
| Purity | >98% |
| Synonyms | AG1478, AG 1478 |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
AG-490
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Also inhib…
CO-1686 (Rociletinib, AVL-301)
CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor …
CL-387785 (EKI-785)
CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a f…
Erlotinib HCl
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
BMS-690514
BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor (EGFR), HER2, and HER4, as well as the VEGF receptor kina…
Arry-380 analog
ARRY-380 is an ErbB-2 inhibitor that selectively binds to and inhibits the phosphorylation of ErbB-2, resulting in growth inhibition and dea…
PKC 412 (Midostaurin)
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B,…
Keywords:buy AG-1478 (Tyrphostin AG-1478) | AG-1478 (Tyrphostin AG-1478) Supplier | purchase | cost | manufacturer | order | distributor | buy 153436-53-4| 153436-53-4 Supplier | purchase 153436-53-4 | 153436-53-4 cost | 153436-53-4 manufacturer | order 153436-53-4 | 153436-53-4 distributor
Adooq Quality Guarantee
We promise all products perform as described.