Tyrphostin AG 879

Name: Tyrphostin AG 879
Brand: Adooq Bioscience
SKU: A10053
Rating: 100 (268 reviews)

Catalog No.: A10053

HER2 inhibitor

Tyrphostin AG 879 Chemical Structure

CAS NO. 148741-30-4

Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA.

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $25.00 Special Price $20.00
10 mg	Regular Price: $40.00 Special Price $32.00
25 mg	Regular Price: $80.00 Special Price $64.00
50 mg	Regular Price: $140.00 Special Price $112.00
10mM * 1mL in DMSO	Regular Price: $75.00 Special Price $60.00
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

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Biological Activity

Tyrphostin AG 879 is an inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA.

Targets

HER2-Neu	Trk	PDGFR	EGFR
1.0 μM	10 μM	>100 μM	>500 μM

Solubility *

In vitro (25°C)	DMSO	35 mg/mL (110.59 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (9.47 mM)
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.6 mL	157.98 mL	315.96 mL
0.5 mM	6.32 mL	31.6 mL	63.19 mL
1 mM	3.16 mL	15.8 mL	31.6 mL
5 mM	0.63 mL	3.16 mL	6.32 mL

*The above data is based on the productmolecular weight 316.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10053
Actions	Inhibitor
CAS No.	148741-30-4
Formula	C18H24N2OS
M. Wt	316.5
Solubility	DMSO
Purity	>98%
Synonyms	AG879
SMILES	CC(C)(C)C1=CC(=C/C(=C(/N)\S)/C#N)C=C(C1=O)C(C)(C)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.