INCB28060

c-MET Inhibitor

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Catalog No. A11132

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
INCB28060 5mg A11132-5

Regular Price: $60.00

Special Price: $48.00

INCB28060 10mg A11132-10

Regular Price: $90.00

Special Price: $72.00

INCB28060 25mg A11132-25

Regular Price: $180.00

Special Price: $144.00

INCB28060 50mg A11132-50

Regular Price: $250.00

Special Price: $200.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.

INCB28060

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Chemical Information

Catalog Num A11132
Actions Inhibitor
M. Wt 412.4
Formula C23H17FN6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1029712-80-8
Synonyms INCB-28060, INC-280, INC280
SMILES code CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
Chemical Name 2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide

Biological Activity

Description
INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.
Targets
c-Met (Cell-free assay)
0.13 nM

Solubility

Solubility (25°C)* In vitro DMSO 2 mg/mL (4.84 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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