LRRK2-IN-1

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Catalog No. A11477

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
LRRK2-IN-1 10mg A11477-10

Regular Price: $110.00

Special Price: $93.50

LRRK2-IN-1 25mg A11477-25

Regular Price: $230.00

Special Price: $195.50

LRRK2-IN-1 50mg A11477-50

Regular Price: $400.00

Special Price: $340.00

LRRK2-IN-1 10mM * 1mL in DMSO A11477-10mM-D

Regular Price: $120.00

Special Price: $102.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.

LRRK2-IN-1

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Chemical Information

Catalog Num A11477
Actions N/A
M. Wt 570.09
Formula C31H38N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1234480-84-2
Synonyms N/A
SMILES code CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC
Chemical Name 5,11-Dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Biological Activity

Description
LRRK2-IN-1 inhibits both G2019S mutant and wild-type LRRK2 kinase activity with IC50 values of 6 and 13 nM respectively.
Targets
Target Value
DCLK1IC50: 2.61nM
LRRK2(G2019S)IC50: 6nM
LRRK2(WT)IC50: 13nM
DCLK2IC50: 45nM
LRRK2(A2016T)IC50: 2.45μM
LRRK2(A2016T+G2019S)IC50: 3.08μM

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