3'-Azido-3'-deoxy-N6-methyladenosine is a purine nucleoside analogue designed for research applications in cancer biology. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. Additionally, it serves as a versatile click chemistry reagent, featuring an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or DBCO/BCN-functionalized compounds, facilitating bioconjugation studies.
3'-Azido-3'-deoxy-N6-methyladenosine is a purine nucleoside analogue designed for research applications in cancer biology. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inhibiting DNA synthesis and inducing apoptosis. Additionally, it serves as a versatile click chemistry reagent, featuring an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules or DBCO/BCN-functionalized compounds, facilitating bioconjugation studies.
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