3-MPPI is a selective G protein-coupled receptor (GPCR) ligand with a strong affinity for the α1-adrenergic receptor, exhibiting a Ki value of 0.21 nM, while its activity on the 5-HT1A receptor is significantly lower at 50 nM. This compound effectively modulates the signaling pathways associated with the α1-adrenergic receptor. Research applications of 3-MPPI include studies on hypertension, the effects of stress-induced anxiety-like behavior, and investigations into levodopa-induced dyskinesia.
3-MPPI is a selective G protein-coupled receptor (GPCR) ligand with a strong affinity for the α1-adrenergic receptor, exhibiting a Ki value of 0.21 nM, while its activity on the 5-HT1A receptor is significantly lower at 50 nM. This compound effectively modulates the signaling pathways associated with the α1-adrenergic receptor. Research applications of 3-MPPI include studies on hypertension, the effects of stress-induced anxiety-like behavior, and investigations into levodopa-induced dyskinesia.
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