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(4R)-BBO-8520

Catalog No.: A63586
KRAS G12C Inhibitor
(4R)-BBO-8520 is a selective inhibitor of the KRAS G12C mutant. This compound effectively impedes the KRAS G12C (ON) signaling, thereby inhibiting cell proliferation by blocking the interaction with GTP. Additionally, (4R)-BBO-8520 disrupts the RAS-RAF1 interaction, facilitating the return of KRAS G12C to its inactive (OFF) state. It is particularly valuable for research applications focused on cancer biology and therapeutics targeting KRAS-driven malignancies.
(4R)-BBO-8520 2893809-52-2 KRAS G12C Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$315.00
In stock
5mg
$565.00
In stock
10mg
$805.00
In stock
25mg
$1,295.00
In stock
50mg
$1,935.00
In stock
100mg
$2,830.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(4R)-BBO-8520 is a selective inhibitor of the KRAS G12C mutant. This compound effectively impedes the KRAS G12C (ON) signaling, thereby inhibiting cell proliferation by blocking the interaction with GTP. Additionally, (4R)-BBO-8520 disrupts the RAS-RAF1 interaction, facilitating the return of KRAS G12C to its inactive (OFF) state. It is particularly valuable for research applications focused on cancer biology and therapeutics targeting KRAS-driven malignancies.
Product Information
Catalog NumA63586
FormulaC35H33F6N7O2S
Molecular Weight729.74
CAS Number2893809-52-2
SMILESFC1=[C@@](C(C(F)(F)F)=CC2=C(N=C(N=C21)OC[C@@]34CCCN3C[C@@H](C4)F)N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C)[C@@]6=CC=C(F)C7=C6C(C#N)=C(N)S7
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Cell Cycle > Ras