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KRAS G12C inhibitor 52

Catalog No.: A63630
KRAS G12C Inhibitor
KRAS G12C inhibitor 52 is a selective inhibitor targeting the KRAS G12C mutant protein. This compound effectively disrupts KRAS signaling pathways, thereby inhibiting cell proliferation and survival in KRAS G12C-driven cancers. Its research applications include studies on cancer biology, drug development, and understanding resistance mechanisms in targeted therapies.
KRAS G12C inhibitor 52 2761204-87-7 KRAS G12C Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionKRAS G12C inhibitor 52 is a selective inhibitor targeting the KRAS G12C mutant protein. This compound effectively disrupts KRAS signaling pathways, thereby inhibiting cell proliferation and survival in KRAS G12C-driven cancers. Its research applications include studies on cancer biology, drug development, and understanding resistance mechanisms in targeted therapies.
Product Information
Catalog NumA63630
FormulaC34H32F2N8O3S
Molecular Weight670.73
CAS Number2761204-87-7
SMILESC=CC(N1C[C@H]2N(C[C@H]1C)C(C3=CC(F)=C(N=C3N(C4=O)C5=C(C=CN=C5C(C)C)C)C6=C7N=C(SC7=C(C=C6)F)N)=C4N(C)C2=O)=O
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Cell Cycle > Ras