Fig. 1 · Structure
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(6S)-CP-470711
SDH Inhibitor
(6S)-CP-470711 is a potent inhibitor of sorbitol dehydrogenase (SDH), demonstrating an IC50 of 19 nM against human SDH and 27 nM against rat SDH. This compound has been shown to mitigate diabetes induced by streptozotocin in rat models, making it a valuable tool for studying diabetic pathophysiology and the role of SDH in glucose metabolism. Its specificity and efficacy provide a basis for further exploration of potential therapeutic applications in metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 300552-09-4 |
| Applications | SDH Inhibitor |
| Formula | C18H26N6O2 |
| Molecular Weight | 358.44 |
| SMILES | C[C@@H]1N(C2=NC([C@@H](O)C)=NC=C2)[C@@H](CN(C3=NC([C@H](O)C)=NC=C3)C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.