7,4'-Dimethoxy-3-hydroxyflavone is a selective antagonist of Protease-Activated Receptor 4 (PAR4). It exhibits potent inhibition of PAR4-mediated human platelet aggregation with an IC50 value of 1.4 μM, effectively disrupting various PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK, and p38. This compound demonstrates potential therapeutic benefits in reducing vascular PAR4 expression and alleviating endothelial dysfunction and oxidative stress in diabetic models. Additionally, 7,4'-Dimethoxy-3-hydroxyflavone has been shown to prevent thrombosis in mice without prolonging bleeding time, suggesting its usefulness in cardiovascular research.
7,4'-Dimethoxy-3-hydroxyflavone is a selective antagonist of Protease-Activated Receptor 4 (PAR4). It exhibits potent inhibition of PAR4-mediated human platelet aggregation with an IC50 value of 1.4 μM, effectively disrupting various PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK, and p38. This compound demonstrates potential therapeutic benefits in reducing vascular PAR4 expression and alleviating endothelial dysfunction and oxidative stress in diabetic models. Additionally, 7,4'-Dimethoxy-3-hydroxyflavone has been shown to prevent thrombosis in mice without prolonging bleeding time, suggesting its usefulness in cardiovascular research.
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