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- SIFEI HAN, .et al. Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug, J Pharm Sci, 2016, Feb;105(2):786-796 PMID: 6540595
Biological Activity
A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).
Targets
| human DGAT-1 | mouse DGAT-1 | DGAT-2 | ||
| 7 nM | 24 nM | 53 μM |
| In vitro (25°C) | DMSO | 83 mg/mL (193.7 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 15% Captisol | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.34 mL | 116.69 mL | 233.38 mL |
| 0.5 mM | 4.67 mL | 23.34 mL | 46.68 mL |
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11199 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 959122-11-3 |
| Formula | C26H24N2O4 |
| M. Wt | 428.48 |
| Purity | >98% |
| Synonyms | DGAT-1 Inhibitor 4a, A-922500, A922500 |
| SMILES | C1C[C@H]([C@@H](C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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