ABT-255 hydrochloride is an orally active antibacterial agent targeting Mycobacterium tuberculosis. It demonstrates potent in vitro activity with a minimum inhibitory concentration (MIC) ranging from 0.016 to 0.031 μg/mL against both drug-susceptible and resistant strains, including those resistant to Rifampin and Ethambutol. Additionally, ABT-255 hydrochloride exhibits efficacy against Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, effectively reducing viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. This compound is valuable for research applications focused on pulmonary tuberculosis.
ABT-255 hydrochloride is an orally active antibacterial agent targeting Mycobacterium tuberculosis. It demonstrates potent in vitro activity with a minimum inhibitory concentration (MIC) ranging from 0.016 to 0.031 μg/mL against both drug-susceptible and resistant strains, including those resistant to Rifampin and Ethambutol. Additionally, ABT-255 hydrochloride exhibits efficacy against Gram-positive and Gram-negative bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli, effectively reducing viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. This compound is valuable for research applications focused on pulmonary tuberculosis.
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