AMS-17 is a potent inhibitor of the NLRP3 inflammasome, effectively suppressing microglial activation both in vitro and in vivo. It demonstrates the ability to inhibit the production of key pro-inflammatory cytokines, including caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS) in N9 cells. This compound is valuable for research focused on inflammation-associated neurological disorders, such as vascular dementia (VaD).
AMS-17 is a potent inhibitor of the NLRP3 inflammasome, effectively suppressing microglial activation both in vitro and in vivo. It demonstrates the ability to inhibit the production of key pro-inflammatory cytokines, including caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS) in N9 cells. This compound is valuable for research focused on inflammation-associated neurological disorders, such as vascular dementia (VaD).
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