AMS-17

Catalog No.: A35571
NLRP3 Inhibitor
AMS-17 is a potent inhibitor of the NLRP3 inflammasome, effectively suppressing microglial activation both in vitro and in vivo. It demonstrates the ability to inhibit the production of key pro-inflammatory cytokines, including caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS) in N9 cells. This compound is valuable for research focused on inflammation-associated neurological disorders, such as vascular dementia (VaD).
Grouped product items
Size Price Stock Qty
5mg
$240.00
In stock
10mg
$380.00
In stock
25mg
$765.00
In stock
50mg
$1,120.00
In stock
100mg
$1,640.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAMS-17 is a potent inhibitor of the NLRP3 inflammasome, effectively suppressing microglial activation both in vitro and in vivo. It demonstrates the ability to inhibit the production of key pro-inflammatory cytokines, including caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS) in N9 cells. This compound is valuable for research focused on inflammation-associated neurological disorders, such as vascular dementia (VaD).
Product Information
Catalog NumA35571
FormulaC15H13F3N4O3S
Molecular Weight386.35
CAS Number3019885-78-7
SMILESO=C1N(CCCN1S(=O)(C2=CC=C(C=C2)C(F)(F)F)=O)C3=CN=CN=C3
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