Antibacterial Agent 254 is an activator of the dispersion sensor DspS, effectively dispersing biofilms formed by Pseudomonas aeruginosa. At a concentration of 50 μM, this compound can successfully dislodge mature, 7-day-old biofilms. Additionally, Antibacterial Agent 254 enhances the antibacterial activity of Ciprofloxacin against P. aeruginosa and upregulates the expression of key matrix-degrading enzyme genes, including pelA, pslG, and eddA. These properties make it a valuable tool for research into biofilm inhibition and bacterial resistance mechanisms.
Antibacterial Agent 254 is an activator of the dispersion sensor DspS, effectively dispersing biofilms formed by Pseudomonas aeruginosa. At a concentration of 50 μM, this compound can successfully dislodge mature, 7-day-old biofilms. Additionally, Antibacterial Agent 254 enhances the antibacterial activity of Ciprofloxacin against P. aeruginosa and upregulates the expression of key matrix-degrading enzyme genes, including pelA, pslG, and eddA. These properties make it a valuable tool for research into biofilm inhibition and bacterial resistance mechanisms.
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