Antifungal Agent 137 (Compound 4S) primarily targets lanosterol 14α-demethylase (CYP51) and exhibits potent antifungal activity against Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL and an IC50 of 5.00 μg/mL. This compound disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces oxidative stress by increasing intracellular reactive oxygen species levels. Antifungal Agent 137 is suitable for research applications focused on fungal infections and antifungal mechanisms.
Antifungal Agent 137 (Compound 4S) primarily targets lanosterol 14α-demethylase (CYP51) and exhibits potent antifungal activity against Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL and an IC50 of 5.00 μg/mL. This compound disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces oxidative stress by increasing intracellular reactive oxygen species levels. Antifungal Agent 137 is suitable for research applications focused on fungal infections and antifungal mechanisms.
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