Apoptosis related

Cat. No.

A13441

CAS No.

355406-76-7

RIPGBM

RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ??500 nM.

Cat. No.

A14474

CAS No.

39524-08-8

Asperosaponin VI

Asperosaponin VI, A saponin component from Dipsacus asper wall, induces osteoblast differentiation through BMP?\2/p38 and ERK1/2 pathway. Asperosaponin ?? inhibits apoptosis in hypoxia-induced cardiomyocyte by increasing the Bcl-2/Bax ratio and decreasing active caspase-3 expression, as well as enhancing of p-Akt and p-CREB.

Cat. No.

A17544

CAS No.

89-83-8

Thymol

Synonyms: NSC 11215

Thymol is a phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge.

Cat. No.

A17642

CAS No.

5578-73-4

Sanguinarine chloride

Synonyms: Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride

Sanguinarine chloride is a benzophenanthridine alkaloid that functions as an apoptosis inducer primarily through the generation of reactive oxygen species (ROS). This compound is known to activate key signaling pathways, specifically JNK and NF-κB, facilitating programmed cell death. Sanguinarine chloride is widely utilized in cancer research and studies investigating apoptotic mechanisms.

Cat. No.

A20373

CAS No.

1323403-33-3

Iberdomide

Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.

Cat. No.

A22208

CAS No.

2041072-41-5

ICCB280

ICCB280 is a potent inducer of C/EBPα.

Cat. No.

A22449

CAS No.

458-36-6

Coniferaldehyde

Synonyms: Ferulaldehyde

Coniferaldehyde (Ferulaldehyde), isolated from the ethanol extract of Vitex rotundifolia fruits, is an effective inducer of heme oxygenase-1 (HO-1).

Cat. No.

A24790

CAS No.

142741-24-0

Conophylline

Conophylline is a vinca alkaloid derived from the leaves of the tropical plant Ervatamia microphylla. This compound functions as a differentiation inducer for pancreatic cells and demonstrates potent biological activity by suppressing hepatic stellate cells (HSC) while inducing apoptosis. It is of particular interest in research focused on pancreatic differentiation and the modulation of liver fibrosis.

Cat. No.

A24889

CAS No.

191545-24-1

epi-Eriocalyxin A

epi-Eriocalyxin A is a diterpenoid compound that serves as an apoptosis inducer in colon cancer cells. It effectively inhibits the activation of ERK1/2 and JNK pathways, leading to the suppression of Bcl-2 expression. This compound is valuable for research focused on cancer treatment and the mechanisms of apoptosis.