MDM2

Cat. No.

A10657

CAS No.

548472-68-0

Nutlin-3

MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.

Cat. No.

A18917

CAS No.

2249750-27-2

Nutlin carboxylic acid

Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs.

Cat. No.

A30156

CAS No.

2713618-08-5

Seldegamadlin

Synonyms: KT-253

Seldegamadlin is a selective p53 stabilizer and an MDM2 PROTAC degrader with a DC50 of 0.4 nM. It effectively inhibits the proliferation of RS4;11 cancer cells, demonstrating an IC50 of 0.3 nM, and induces cell cycle arrest at the G2/M phase while promoting apoptosis. By upregulating p53 activity, Seldegamadlin overcomes the p53-MDM2 feedback loop, making it a valuable tool for research in hematologic and solid tumors, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Cat. No.

A53803

CAS No.

1410737-09-5

MDM2 ligand 5

MDM2 Ligand 5 is a potent ligand targeting the MDM2 protein, known for its role in regulating p53 activity. This compound serves as a critical building block for the development of Proteolysis Targeting Chimeras (PROTACs), facilitating the selective degradation of MDM2 to enhance p53-mediated tumor suppression. MDM2 Ligand 5 is valuable for research applications focused on cancer therapeutics and the modulation of oncogenic pathways.

Cat. No.

A80605

CAS No.

2760669-71-2

(rel)-Nutlin carboxylic acid

(rel)-Nutlin carboxylic acid is an MDM2 ligand derived from Nutlin 3, targeting the MDM2 protein to inhibit its interaction with p53. This compound plays a crucial role in cancer research, particularly in the study of p53 pathway modulation and potential therapeutic interventions. It can also be utilized in the development of PROTACs when linked to other proteins, facilitating targeted protein degradation.