HDAC6

Cat. No.

A10246

CAS No.

1012054-59-9

CUDC-101

CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

Cat. No.

A10764

CAS No.

382180-17-8

Pyroxamide (NSC 696085)

Synonyms: NSC-696085

Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent.

Cat. No.

A10954

CAS No.

537049-40-4

Tubacin

Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.

Cat. No.

A11355

CAS No.

251456-60-7

M344

Synonyms: Histone Deacetylase Inhibitor III,MS344

M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation.

Cat. No.

A11940

CAS No.

1316214-52-4

ACY-1215 (Rocilinostat)

Synonyms: ACY1215

ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.

Cat. No.

A12456

CAS No.

1375466-18-4

ACY-775

ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5 nM.

Cat. No.

A12722

CAS No.

287383-59-9

Scriptaid

Scriptaid is an HDAC inhibitor (histone deacetylase).

Cat. No.

A12911

CAS No.

1423058-85-8

BRD9757

BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.

Cat. No.

A14032

CAS No.

1403783-31-2

Nexturastat A

Synonyms: Nexturastat-A,NexturastatA

Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM).

Cat. No.

A14341

CAS No.

1418033-25-6

LMK-235

LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.

Cat. No.

A16770

CAS No.

1252003-15-8

Tubastatin A

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more).

Cat. No.

A18947

CAS No.

2126744-35-0

SW-100

SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes.

Cat. No.

A21126

CAS No.

497833-27-9

Givinostat

Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.

Cat. No.

A26475

CAS No.

1267502-34-0

FNDR-20123 free base

FNDR-20123 free base is a potent, orally active anti-malarial agent that functions as a histone deacetylase (HDAC) inhibitor. It demonstrates significant inhibitory activity against Plasmodium falciparum, achieving IC50 values of 41 nM during the asexual stage and 190 nM for male gametocytes. In addition, FNDR-20123 free base selectively inhibits various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with respective IC50 values of 25 nM, 29 nM, 2 nM, 11 nM, and 282 nM. This compound is a valuable tool for research into the treatment of malaria and the role of HDACs in cellular regulation.

Cat. No.

A12758

CAS No.

1316215-12-9

Citarinostat (ACY-241)

Synonyms: HDAC-IN-2; ACY-241

ACY-241 is a new, selective and orally available inhibitor of HDAC6.

Cat. No.

A11153

CAS No.

1339928-25-4

Fimepinostat (CUDC-907)

Synonyms: CUDC907

CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.

Cat. No.

A11920

CAS No.

128517-07-7

Romidepsin (FK228, Depsipeptide)

Synonyms: FK228; Depsipeptide

Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.

Cat. No.

A15934

CAS No.

1375465-91-0

ACY-738

ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.

Cat. No.

A10516

CAS No.

404951-53-7

Dacinostat (LAQ824, NVP-LAQ824)

Synonyms: LAQ824; NVP-LAQ824

LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.

Cat. No.

A10947

CAS No.

58880-19-6

Trichostatin A (TSA)

Synonyms: TSA

Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.

Cat. No.

A16431

CAS No.

1045792-66-2

CAY10603

CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM, >200-fold selectivity over other HDACs.

Cat. No.

A10518

CAS No.

404950-80-7

Panobinostat (LBH589)

Synonyms: NVP-LBH589; LBH589

LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.

Cat. No.

A10700

CAS No.

783355-60-2

Abexinostat (PCI-24781)

Synonyms: CRA-024781; PCI-24781

PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.

Cat. No.

A10979

CAS No.

149647-78-9

Vorinostat (SAHA)

Synonyms: Zolinza; MK-0683; SAHA

Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.

Cat. No.

A10122

CAS No.

414864-00-9

Belinostat (PXD101)

Synonyms: PX105684

Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.