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Assay Controls & Cell Stimulation

Assay controls and cell stimulation reagents give defined responses that anchor cell-based experiments. Phorbol 12-myristate 13-acetate (PMA) with ionomycin activates T cells, and brefeldin A or monensin retain cytokines for intracellular staining. Staurosporine induces apoptosis, which the pan-caspase inhibitor Z-VAD-FMK blocks, while erastin and RSL3 trigger ferroptosis and ferrostatin-1 prevents it. Mitochondrial stress tests combine oligomycin, FCCP and rotenone, and tunicamycin induces endoplasmic reticulum stress. Bafilomycin A1 and chloroquine block autophagic flux at the lysosome, a standard control in autophagy assays. Nocodazole, thymidine and RO-3306 arrest cells at defined cell cycle stages for synchronization.

2 Items

  • Piperazine Erastin
    Cat. No.
    A27071
    CAS No.
    1538593-71-3

    Piperazine Erastin

    Piperazine Erastin is a ferroptosis inducer that triggers an iron-dependent form of non-apoptotic cell death. This compound is instrumental in cancer research, providing valuable insights into the mechanisms of ferroptosis and potential therapeutic applications in oncology. Its unique action offers a powerful tool for studying cellular metabolism and death pathways in various cancer models.

    In stock View Details
    1 mg
    $70.00
    5 mg
    $145.00
    All 8 sizes
  • Tunicamycin
    Cat. No.
    A33158
    CAS No.
    11089-65-9

    Tunicamycin

    Tunicamycin is an ER stress inducer that inhibits N-linked glycosylation by blocking GlcNAc phosphotransferase (GPT). This action leads to the accumulation of unfolded proteins within the endoplasmic reticulum, resulting in ER stress, DNA synthesis inhibition, and G1 phase cell cycle arrest. Additionally, Tunicamycin exhibits antimicrobial activity against gram-positive bacteria, yeasts, fungi, and viruses while demonstrating anti-cancer potential. Notably, it also enhances exosome release in cervical cancer cells, making it valuable for research in cancer biology and cellular stress response pathways.

    In stock View Details
    1 mg
    $50.00
    2 mg
    $75.00
    All 5 sizes

2 Items

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