Inducible Expression & Protein Degradation Tags

Inducible expression and protein degradation systems switch a gene or a protein on or off with a small molecule. In tetracycline-controlled (Tet-On) systems, doxycycline activates transcription of the target gene. 4-Hydroxytamoxifen activates Cre recombinase fused to a modified estrogen receptor (CreER), and isopropyl β-D-1-thiogalactopyranoside (IPTG) induces lac-controlled genes in bacteria. Chemical inducers of dimerization such as AP20187 and abscisic acid bring fusion proteins together on demand. Degron systems remove tagged proteins within hours, with dTAG-13 for FKBP12 F36V fusions and 5-Ph-IAA for the auxin-inducible degron 2 (AID2) system. Shield-1 offers a further switch, as it stabilizes proteins fused to a destabilizing domain.

9 Items

  • Sirolimus
    Cat. No.
    A10782

    Sirolimus (Rapamycin)

    Synonyms: Rapamune; Rapamycin

    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).

    5 mg
    $25.00
    10 mg
    $25.00
    All 11 sizes
  • Doxycycline hyclate
    Cat. No.
    A16519

    Doxycycline hyclate

    Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

    Doxycycline hyclate is a broad-spectrum antibiotic and an effective metalloproteinase (MMP) inhibitor. It demonstrates significant antibacterial properties as well as the ability to inhibit cancer cell proliferation. This compound is valuable for constructing models of gene expression regulation in various biological research applications.

    100 mg
    $35.00
    1 g
    $40.00
    All 6 sizes
  • Doxycycline
    Cat. No.
    A17545

    Doxycycline

    Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

    25 mg
    $40.00
    50 mg
    $65.00
    All 6 sizes
  • Doxycycline monohydrate
    Cat. No.
    A17813

    Doxycycline monohydrate

    Synonyms: Adoxa; Doxycycline; GS-3065; Monodox; Oracea; Vibramycin

    Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.

    25 mg
    $20.00
    50 mg
    $35.00
    All 5 sizes
  • 4-Isopropylbenzoic acid
    Cat. No.
    A28540

    4-Isopropylbenzoic acid

    Synonyms: Cuminic acid; p-Isopropyl benzoic acid

    4-Isopropylbenzoic acid is an aromatic monoterpenoid known for its antifungal properties. Isolated from the stem bark of Bridelia retusa, this compound demonstrates significant activity against various fungal strains. Additionally, it acts as a reversible and uncompetitive inhibitor of mushroom tyrosinase, making it relevant in studies related to enzymatic inhibition and fungal pathogen research.

    1 g
    $25.00
    5 g
    $35.00
    All 3 sizes
  • Doxycycline calcium
    Cat. No.
    A46581

    Doxycycline calcium

    Doxycycline calcium is a broad-spectrum antibiotic that serves as a metalloproteinase (MMP) inhibitor. This compound demonstrates antibacterial properties and inhibits cancer cell proliferation, making it valuable in cancer research. Additionally, doxycycline calcium can be utilized in constructing gene expression regulation models, providing insights into gene modulation and environmental response mechanisms.

    Out of stock

    All 3 sizes
  • IPTG
    Cat. No.
    A86381

    IPTG

    Synonyms: Isopropyl β-D-thiogalactoside

    IPTG (Isopropyl β-D-1-thiogalactopyranoside) acts as a molecular mimic of allolactose and serves as an inducer of the lac operon. This compound effectively triggers transcription in systems where gene expression is regulated by the lac operator, enabling controlled protein expression in biological research. IPTG is widely utilized in molecular biology and recombinant protein studies to regulate the activity of target genes within prokaryotic expression systems.

    500 mg
    $35.00
    1 g
    $40.00
    All 5 sizes
  • IPTG hemidioxane
    Cat. No.
    A91745

    IPTG hemidioxane

    Synonyms: β-D-1-thiogalactopyranoside hemidioxane

    IPTG hemidioxane, also known as β-D-1-thiogalactopyranoside hemidioxane, serves as a potent biochemical reagent primarily utilized as an inducer of the lac operon in molecular biology research. It effectively promotes the expression of proteins in bacterial systems, enhancing the study of gene function and protein production. This reagent is essential for assays requiring controlled gene expression and is widely used in recombinant protein technology.

    Out of stock

    All 3 sizes
  • GA3-AM
    Cat. No.
    B18068

    GA3-AM

    GA3-AM is a cell-permeable analog of the plant hormone gibberellic acid, functioning as a chemical dimerizer or inducer of dimerization. This compound is valuable for studying gibberellic acid signaling pathways and investigating plant growth and developmental processes. Its ability to facilitate protein-protein interactions makes it a useful tool in biochemical and cellular research.

    1 mg
    $30.00
    5 mg
    $100.00
    All 6 sizes

9 Items

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