Inducible Expression & Protein Degradation Tags

Cat. No.

A10782

CAS No.

53123-88-9

Sirolimus (Rapamycin)

Synonyms: Rapamune; Rapamycin

Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).

Cat. No.

A12532

CAS No.

68392-35-8

(E/Z)-4-hydroxy Tamoxifen

Synonyms: Afimoxifene

(E/Z)-4-hydroxy Tamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

Cat. No.

A10591

CAS No.

84371-65-3

Mifepristone

Synonyms: RU-486; Mifegyne; Mifeprex

Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.

Cat. No.

A10745

CAS No.

10592-13-9

Doxycycline HCl

Synonyms: Vibramycin hydrochloride

Doxycycline Hydrochloride is a synthetic tetracycline derivative with similar antimicrobial activity.

Cat. No.

A13519

CAS No.

195514-63-7

Rimiducid (AP1903)

Synonyms: AP 1903

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.

Cat. No.

A14224

CAS No.

21293-29-8

Abscisic Acid

Synonyms: Abscisin II; Dormin

Abscisic Acid is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism.

Cat. No.

A16519

CAS No.

24390-14-5

Doxycycline hyclate

Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031

Doxycycline hyclate is a broad-spectrum antibiotic and an effective metalloproteinase (MMP) inhibitor. It demonstrates significant antibacterial properties as well as the ability to inhibit cancer cell proliferation. This compound is valuable for constructing models of gene expression regulation in various biological research applications.

Cat. No.

A16766

CAS No.

738-70-5

Trimethoprim

Trimethoprim is a bacteriostatic antibiotic that primarily targets dihydrofolate reductase, inhibiting folate synthesis in bacteria. It exhibits activity against a broad spectrum of Gram-positive and Gram-negative aerobic organisms, making it valuable in the study of urinary tract infections, Shigellosis, and Pneumocystis pneumonia. Additionally, Trimethoprim has demonstrated potential in inhibiting Influenza A virus infection in chick embryos when used in combination with zinc.

Cat. No.

A17545

CAS No.

564-25-0

Doxycycline

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A17813

CAS No.

17086-28-1

Doxycycline monohydrate

Synonyms: Adoxa; Doxycycline; GS-3065; Monodox; Oracea; Vibramycin

Doxycycline monohydrate is an antibiotic and broad-spectrum metalloproteinase (MMP) inhibitor.

Cat. No.

A18992

CAS No.

1708091-24-0

Zapalog

Zapalog is a photocleavable small-molecule heterodimerizer that can be used to repeatedly initiate, and instantaneously terminate, a physical interaction between two target proteins. Zapalog dimerizes any two proteins tagged with the FKBP and DHFR domains until exposure to light causes its photolysis.

Cat. No.

A19833

CAS No.

914805-33-7

Shield-1

Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins.

Cat. No.

A20953

CAS No.

87-51-4

3-Indoleacetic acid

Synonyms: Indole-3-acetic acid; 3-IAA

3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.

Cat. No.

A20955

CAS No.

68047-06-3

4-Hydroxytamoxifen

Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).

Cat. No.

A21127

CAS No.

195514-80-8

AP20187

Synonyms: B/B Homodimerizer

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

Cat. No.

A23908

CAS No.

2064175-41-1

FKBP12 PROTAC dTAG-13

dTAG-13 is a PROTAC-based heterobifunctional degrader that selectively targets FKBP12^F36V fused in-frame to a protein of interest. By engaging both FKBP12^F36V and the cereblon (CRBN) E3 ligase, dTAG-13 induces efficient and selective degradation of FKBP12^F36V-tagged proteins, making it a valuable tool for conditional protein knockdown studies.

Cat. No.

A23939

CAS No.

2624313-15-9

dTAGV-1 TFA

dTAGV-1 TFA is a potent and selective degrader of FKBP12^F36V-tagged fusion proteins. It enables efficient in vivo degradation of FKBP12^F36V-Nluc, making it a valuable tool for conditional protein degradation studies in live models.

Cat. No.

A23960

CAS No.

2265886-81-3

dTAG-47

dTAG-47 is a heterobifunctional degrader that selectively targets FKBP12^F36V-tagged proteins for degradation. By binding FKBP12^F36V, which acts as a degradation tag (dTAG), dTAG-47 enables conditional and selective protein degradation. It is a valuable tool for studying protein function in models such as basal-like breast cancer (BBC).

Cat. No.

A24722

CAS No.

2624313-16-0

dTAGV-1 hydrochloride

dTAGV-1 hydrochloride is a highly selective degrader targeting FKBP12F36V-tagged proteins through the PROTAC mechanism. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studies involving targeted protein degradation. Its application in research facilitates the investigation of protein function, dynamics, and the development of therapies that exploit the proteolysis pathway.

Cat. No.

A24824

CAS No.

2451573-87-6

dTAGV-1-NEG

dTAGV-1-NEG is a diastereomer that acts as a heterobifunctional negative control for dTAGV-1, specifically targeted at FKBP12(F36V). This compound is utilized in research to study the selectivity and efficacy of FKBP12(F36V) degraders, helping to elucidate cellular mechanisms and pathways influenced by FKBP12 modulation. Its role as a control reagent makes it essential for validating experimental results in protein degradation studies.

Cat. No.

A24838

CAS No.

2451573-90-1

dTAG-13-NEG

dTAG-13-NEG serves as a negative control for dTAG-13, a PROTAC-based bifunctional degrader that selectively targets FKBP12F36V in the presence of a protein of interest. While dTAG-13 promotes the degradation of FKBP12F36V, dTAG-13-NEG allows for the assessment of specificity and background in experimental setups involving this pathway. This compound is essential for validating experimental results when studying protein degradation mechanisms and their implications in cellular biology.

Cat. No.

A28540

CAS No.

536-66-3

4-Isopropylbenzoic acid

Synonyms: Cuminic acid; p-Isopropyl benzoic acid

4-Isopropylbenzoic acid is an aromatic monoterpenoid known for its antifungal properties. Isolated from the stem bark of Bridelia retusa, this compound demonstrates significant activity against various fungal strains. Additionally, it acts as a reversible and uncompetitive inhibitor of mushroom tyrosinase, making it relevant in studies related to enzymatic inhibition and fungal pathogen research.

Cat. No.

A29178

CAS No.

2990123-10-7

5-Ph-IAA-AM

5-Ph-IAA-AM is a cell-permeable analog of 5-Ph-IAA featuring an acetoxymethyl (AM) group, designed to facilitate enhanced protein degradation within laid embryos. This compound is instrumental in investigating the functions of proteins in C. elegans, particularly those critical to embryogenesis and developmental processes, through temporally controlled protein degradation. Researchers can leverage 5-Ph-IAA-AM to elucidate protein roles and regulatory mechanisms in developmental biology studies.

Cat. No.

A40246

CAS No.

168649-23-8

5-Ph-IAA

5-Ph-IAA is a ligand that specifically interacts with the auxin-inducible degron 2 (AID2) system, in conjunction with the OsTIR1 (F74G) mutant. This compound facilitates the rapid and efficient degradation of mAID-fused proteins, enabling the investigation of protein function in live cells. 5-Ph-IAA is particularly useful in studies related to protein turnover and regulation, offering insights into cellular processes such as tumor suppression. Its application in research enhances the understanding of protein dynamics in various biological contexts.

Cat. No.

A40913

CAS No.

2451573-86-5

dTAGV-1

dTAGV-1 is a selective proteolysis-targeting chimera (PROTAC) degrader designed to target FKBP12F36V-tagged proteins. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studying protein turnover and function. Its application is particularly relevant in cellular and molecular biology research, facilitating the investigation of protein interactions and therapeutic targets.