Inducible Expression & Protein Degradation Tags

Cat. No.

A12532

CAS No.

68392-35-8

(E/Z)-4-hydroxy Tamoxifen

Synonyms: Afimoxifene

(E/Z)-4-hydroxy Tamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

Cat. No.

A20955

CAS No.

68047-06-3

4-Hydroxytamoxifen

Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen

4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).

Cat. No.

A23908

CAS No.

2064175-41-1

FKBP12 PROTAC dTAG-13

dTAG-13 is a PROTAC-based heterobifunctional degrader that selectively targets FKBP12^F36V fused in-frame to a protein of interest. By engaging both FKBP12^F36V and the cereblon (CRBN) E3 ligase, dTAG-13 induces efficient and selective degradation of FKBP12^F36V-tagged proteins, making it a valuable tool for conditional protein knockdown studies.

Cat. No.

A23939

CAS No.

2624313-15-9

dTAGV-1 TFA

dTAGV-1 TFA is a potent and selective degrader of FKBP12^F36V-tagged fusion proteins. It enables efficient in vivo degradation of FKBP12^F36V-Nluc, making it a valuable tool for conditional protein degradation studies in live models.

Cat. No.

A23960

CAS No.

2265886-81-3

dTAG-47

dTAG-47 is a heterobifunctional degrader that selectively targets FKBP12^F36V-tagged proteins for degradation. By binding FKBP12^F36V, which acts as a degradation tag (dTAG), dTAG-47 enables conditional and selective protein degradation. It is a valuable tool for studying protein function in models such as basal-like breast cancer (BBC).

Cat. No.

A24722

CAS No.

2624313-16-0

dTAGV-1 hydrochloride

dTAGV-1 hydrochloride is a highly selective degrader targeting FKBP12F36V-tagged proteins through the PROTAC mechanism. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studies involving targeted protein degradation. Its application in research facilitates the investigation of protein function, dynamics, and the development of therapies that exploit the proteolysis pathway.

Cat. No.

A24824

CAS No.

2451573-87-6

dTAGV-1-NEG

dTAGV-1-NEG is a diastereomer that acts as a heterobifunctional negative control for dTAGV-1, specifically targeted at FKBP12(F36V). This compound is utilized in research to study the selectivity and efficacy of FKBP12(F36V) degraders, helping to elucidate cellular mechanisms and pathways influenced by FKBP12 modulation. Its role as a control reagent makes it essential for validating experimental results in protein degradation studies.

Cat. No.

A24838

CAS No.

2451573-90-1

dTAG-13-NEG

dTAG-13-NEG serves as a negative control for dTAG-13, a PROTAC-based bifunctional degrader that selectively targets FKBP12F36V in the presence of a protein of interest. While dTAG-13 promotes the degradation of FKBP12F36V, dTAG-13-NEG allows for the assessment of specificity and background in experimental setups involving this pathway. This compound is essential for validating experimental results when studying protein degradation mechanisms and their implications in cellular biology.

Cat. No.

A40913

CAS No.

2451573-86-5

dTAGV-1

dTAGV-1 is a selective proteolysis-targeting chimera (PROTAC) degrader designed to target FKBP12F36V-tagged proteins. This compound effectively induces the degradation of FKBP12F36V-Nluc in vivo, making it a valuable tool for studying protein turnover and function. Its application is particularly relevant in cellular and molecular biology research, facilitating the investigation of protein interactions and therapeutic targets.