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Inducible Expression & Protein Degradation Tags

Inducible expression and protein degradation systems switch a gene or a protein on or off with a small molecule. In tetracycline-controlled (Tet-On) systems, doxycycline activates transcription of the target gene. 4-Hydroxytamoxifen activates Cre recombinase fused to a modified estrogen receptor (CreER), and isopropyl β-D-1-thiogalactopyranoside (IPTG) induces lac-controlled genes in bacteria. Chemical inducers of dimerization such as AP20187 and abscisic acid bring fusion proteins together on demand. Degron systems remove tagged proteins within hours, with dTAG-13 for FKBP12 F36V fusions and 5-Ph-IAA for the auxin-inducible degron 2 (AID2) system. Shield-1 offers a further switch, as it stabilizes proteins fused to a destabilizing domain.

2 Items

  • (E/Z)-4-hydroxy Tamoxifen
    Cat. No.
    A12532
    CAS No.
    68392-35-8

    (E/Z)-4-hydroxy Tamoxifen

    Synonyms: Afimoxifene

    (E/Z)-4-hydroxy Tamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.

    In stock View Details
    5 mg
    $40.00
    10 mg
    $65.00
    All 8 sizes
  • 4-Hydroxytamoxifen
    Cat. No.
    A20955
    CAS No.
    68047-06-3

    4-Hydroxytamoxifen

    Synonyms: (Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen

    4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).

    In stock View Details
    5 mg
    $55.00
    10 mg
    $80.00
    All 6 sizes

2 Items

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