We use analytics and advertising cookies, which you can accept or reject; see our privacy policy.

Current choice:

Solid Tumor Antigens

Solid tumor antigen antibodies bind surface proteins overexpressed on carcinoma, sarcoma or neuroblastoma cells. Zolbetuximab targets claudin 18.2, and enfortumab binds Nectin-4, an adhesion protein that is common in urothelial cancer. Sacituzumab and datopotamab bind trophoblast cell-surface antigen 2 (TROP2), and mirvetuximab binds folate receptor alpha (FRĪ±). Dinutuximab recognizes the disialoganglioside GD2, and labetuzumab binds carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). Many of these antibodies are the targeting component of antibody-drug conjugates used in internalization, payload delivery and cytotoxicity studies.

5 Items

  • Lexatumumab — antibody illustration
    Cat. No.
    AT0457
    CAS No.
    845816-02-6

    Lexatumumab

    Synonyms: HGS-ETR 2; ETR2-ST01

    Lexatumumab (HGS-ETR 2) is a human monoclonal antibody of the IgG4Īŗ subtype that functions as an agonist to TRAIL receptor 2 (TRAIL-R2, also known as DR5 or APO-2). This antibody is specifically designed to induce apoptosis in cells exhibiting malignant mesothelioma characteristics. It is primarily utilized in research focused on understanding and treating malignant pleural mesothelioma (MPM), offering significant value in studies aimed at exploring targeted cancer therapies.

    In stock View Details
    1 mg
    $208.00
    5 mg
    $624.00
    All 3 sizes
  • Drozitumab — antibody illustration
    Cat. No.
    AT0622
    CAS No.
    912628-39-8

    Drozitumab

    Synonyms: PRO 95780; rhuMAb-DR 5; Anti-Human DR5 Recombinant Antibody

    Drozitumab (PRO 95780) is a human agonistic monoclonal antibody designed to specifically target and bind to the death receptor DR5. This interaction promotes apoptosis in tumor cells, thereby exhibiting potent antitumor activity. Drozitumab has demonstrated significant efficacy against rhabdomyosarcoma in research settings, making it a valuable tool for studies focused on this type of cancer.

    In stock View Details
    1 mg
    $240.00
    5 mg
    $720.00
    All 3 sizes
  • Benufutamab — antibody illustration
    Cat. No.
    AT0737
    CAS No.
    2109730-69-8

    Benufutamab

    Synonyms: GEN1029

    Benufutamab (GEN1029) is an agonistic antibody targeting death receptor 5 (DR5), designed to selectively initiate apoptosis in tumor cells. This biologic is composed of two non-competing, DR5-specific IgG1 antibodies, each engineered with an E430G mutation in the Fc domain to enhance its therapeutic efficacy. Benufutamab demonstrates significant antitumor activity, making it a valuable tool for research in cancer therapy and apoptosis mechanisms.

    In stock View Details
    1 mg
    $400.00
    5 mg
    $1,200.00
    All 3 sizes
  • Tilogotamab — antibody illustration
    Cat. No.
    AT1303
    CAS No.
    2109731-10-2

    Tilogotamab

    Synonyms: HexaBody-DR5/DR5; Hx-DR5-01/05

    Tilogotamab is an enhanced agonistic formulation composed of two antibodies, each targeting distinct epitopes on death receptor type 5 (DR5). This specific interaction with DR5 facilitates its activation, making Tilogotamab a valuable tool in the study of multiple myeloma (MM). This product is designed for research use, focusing on elucidating the pathways and mechanisms associated with DR5 in multiple myeloma.

    In stock View Details
    1 mg
    $240.00
    5 mg
    $720.00
    All 3 sizes
  • Conatumumab — antibody illustration
    Cat. No.
    AT1457
    CAS No.
    896731-82-1

    Conatumumab

    Synonyms: AMG 655; TRAIL-R2 mAb; Human Anti-TNFRSF10B Recombinant Antibody

    Conatumumab (AMG 655) is a human monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2), displaying high affinity with dissociation constants (Kd) of 1 nM for the long form of DR5 and 0.8 nM for the short form. This antibody functions by inducing apoptosis through caspase activation, making it highly relevant for cancer research applications.

    In stock View Details
    1 mg
    $368.00
    5 mg
    $920.00
    All 3 sizes

5 Items

Added to your cart

View Cart Checkout

    Loading...