Calpain-1 substrate, fluorogenic

Catalog No.: B11264
Fluorescent Substrate
Calpain-1 substrate, fluorogenic is a sensitive and specific substrate designed for detecting calpain-1 activity. This substrate is cleaved at the Tyr-Gly bond, resulting in enhanced fluorescence detectable at excitation/emission wavelengths of 490 nm/518 nm. It is valuable in studying calpain-related processes and evaluating the role of calpain-1 in various biological contexts.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionCalpain-1 substrate, fluorogenic is a sensitive and specific substrate designed for detecting calpain-1 activity. This substrate is cleaved at the Tyr-Gly bond, resulting in enhanced fluorescence detectable at excitation/emission wavelengths of 490 nm/518 nm. It is valuable in studying calpain-related processes and evaluating the role of calpain-1 in various biological contexts.
Product Information
Catalog NumB11264
FormulaC79H95N13O19S2
Molecular Weight1594.81
CAS Number636566-40-0
Sequence{Lys(FAM)}-Glu-Val-Tyr-Gly-Met-Met-{Lys(DABCYL)}
Sequence shortening{Lys(FAM)}-EVYGMM-{Lys(DABCYL)}
SMILESO=C1OC2(C=3C1=CC(C(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCCCNC(=O)C5=CC=C(N=NC6=CC=C(N(C)C)C=C6)C=C5)C(O)=O)=O)CCSC)=O)CCSC)=O)=O)=O)C(C)C)=O)CCC(O)=O)=O)N)=O)=CC3)C=7C(OC=8C2=CC=C(O)C8)=CC(O)=CC7
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