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Ferroptosis

Ferroptosis inducers and inhibitors are used to study an iron-dependent form of regulated cell death. The term was introduced in 2012 for erastin-triggered cell death that differs from apoptosis and requires iron. Erastin depletes glutathione by inhibiting system xc-, the cystine/glutamate antiporter that supplies cysteine to cells. Glutathione peroxidase 4 (GPX4) reduces phospholipid hydroperoxides, and its inhibition lets lipid peroxidation accumulate to lethal levels. RSL3 and ML-210 inhibit GPX4 directly and are standard inducers in cell models. Ferrostatin-1 and liproxstatin-1 act in the opposite direction by trapping lipid radicals. Liproxstatin-1 protected mice with inducible Gpx4 deletion from acute renal failure in a 2014 study. Iron chelators such as deferiprone help to confirm the iron dependence of the process.

2 Items

  • PROTAC NCOA4 degrader-1
    Cat. No.
    A23976

    PROTAC NCOA4 degrader-1

    PROTAC NCOA4 Degrader-1 (Compound V3) is a highly potent PROTAC targeting NCOA4, with a DC₅₀ of 3 nM in HeLa cells. It functions as a ferroptosis inhibitor by reducing NCOA4 levels and lowering intracellular ferrous iron (Fe²⁺) concentrations. PROTAC NCOA4 Degrader-1 has demonstrated protective effects in a CCl₄-induced acute liver injury model, making it a valuable tool for studying ferroptosis and liver disease therapeutics.

    In stock View Details
    5 mg
    $810.00
    10 mg
    $1,395.00
    All 4 sizes
  • DB1113
    Cat. No.
    A24837
    CAS No.
    2769753-53-7

    DB1113

    DB1113 is a bifunctional compound designed for targeted protein degradation of various kinases. It effectively induces degradation of ABL1, ABL2, BLK, CDK4, CDK11B, EPHA3, MAPK7, RIPK1, and others, facilitating the investigation of kinase-related signaling pathways. DB1113 is suitable for research focusing on diseases or disorders associated with dysregulated kinase activity, providing a valuable tool for exploring therapeutic interventions in cancer and other conditions.

    In stock View Details
    5 mg
    $695.00
    10 mg
    $1,220.00
    All 2 sizes

2 Items

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