Transglutaminase 2 (TG2) Inhibitors & Degraders

Cat. No.: A34283

CAS No.: 3054388-18-7

PROTAC TG2 Degrader-3

PROTAC TG2 Degrader-3 functions as a targeted protein degrader specifically for transglutaminase 2 (TG2). This compound effectively inhibits the adhesion and migration of ovarian cancer cells, making it a valuable tool for research focused on ovarian cancer biology and therapeutics. By facilitating the degradation of TG2, it provides insights into the modulation of cancer cell behavior and the potential development of novel treatments.

View Details

Out of stock

All 3 sizes

Cat. No.: A74971

CAS No.: 3033465-51-6

PROTAC TG2 degrader-2

PROTAC TG2 Degrader-2 is a selective degrader that targets Transglutaminase 2 (TG2). This compound effectively inhibits cell migration and reduces TG2 levels in ovarian cancer cells, making it a valuable tool for research into ovarian cancer biology. Its ability to modulate TG2 offers insights into potential therapeutic strategies against this malignancy.

In stock View Details

All 4 sizes

Cat. No.: A74987

CAS No.: 3033465-55-0

PROTAC TG2 degrader-1

PROTAC TG2 degrader-1 is a von Hippel-Lindau (VHL)-based PROTAC designed to specifically target tissue transglutaminase (TG2) with a dissociation constant (KD) of 68.9 μM. This compound effectively induces the degradation of TG2 in ovarian cancer cells through a proteasome-dependent mechanism. It serves as a valuable tool for research investigating the role of TG2 in cancer biology and potential therapeutic applications.