Lipoxygenase

Cat. No.

A70409

CAS No.

195454-31-0

Raloxifene N-Oxide

Raloxifene N-Oxide is an oxidative degradation product of Raloxifene, functioning primarily as a selective estrogen receptor modulator (SERM). This compound is of particular interest in research related to estrogen signaling pathways, as it may provide insights into the metabolism and pharmacokinetics of Raloxifene. Its biological activity allows for the exploration of estrogen receptor interactions and implications in conditions such as osteoporosis and breast cancer.

Cat. No.

A76437

CAS No.

121107-97-9

13(S)-HPOTrE(γ)

13(S)-Hydroxy-9,11,13-octadecatrienoic acid (13(S)-HPOTrE(γ) is an endogenously formed monohydroxy polyunsaturated fatty acid that serves as a substrate for soybean lipoxygenase-1 (LO-1) involved in the metabolism of γ-linolenic acid. It exhibits inhibitory effects on soybean LO-1 activity at concentrations exceeding 100 μM, and is also a precursor for the synthesis of all four isomers of 6,13-DiHOTrE. This compound is valuable for research focusing on lipoxygenase activity and the biochemical pathways involving PUFA metabolism.

Cat. No.

A76469

CAS No.

2190-14-9

1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol

Synonyms: 1-Stearin-2-olein-3-linolein; TG(18:0/18:1/18:2)

1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol serves as a substrate for lipoxygenase enzymes, playing a critical role in the formation of bioactive lipids. This compound is involved in various biological processes, including inflammation and cellular signaling pathways. Its application in research includes studies on lipid metabolism and the role of lipoxygenases in disease models.

Cat. No.

A76484

CAS No.

136668-70-7

L-691831

L-691831 is a potent ligand for the 5-lipoxygenase activating protein (FLAP). It is primarily utilized in binding assays to explore FLAP-related activities, particularly in leukocyte membranes. This compound enables the measurement of FLAP affinity for leukotriene synthesis inhibitors, providing insights into the mechanisms of leukotriene production and potential therapeutic targets in inflammatory conditions.

Cat. No.

B10915

CAS No.

107656-14-4

9(R)-HETE

Synonyms: 9(R)-Hydroxyeicosatetraenoic acid

9(R)-HETE is an enantiomer of 9-HETE, comprising 50% of the racemic mixture (±)9-HETE. It functions as an activator of RXRγ-dependent transcription, demonstrating a 1.5-fold increase in activity at a concentration of 300 nM compared to controls. The stereochemical characterization of the (R) enantiomer is supported by chiral HPLC retention time comparisons with published data. This compound is valuable for studies investigating RXR signaling pathways and lipid metabolism.