- Cat. No.
- A20640
BMS-779788
Synonyms: EXEL04286652; XL-652; BMS-788
BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.
In stock
View Details
Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Liver X receptor (LXR) agonists and antagonists act on oxysterol-activated nuclear receptors. LXRα and LXRβ were shown in 1996 to respond to oxidized cholesterol derivatives such as 24,25-epoxycholesterol. Through sterol regulatory element-binding protein 1c (SREBP-1c) they link sterol sensing to fatty acid synthesis in liver, and they also drive genes of reverse cholesterol transport. GW3965 and GW3965 HCl are synthetic agonists of both subtypes and are widely used in such gene expression work. T0901317 activates LXR but also acts on the farnesoid X receptor, so selectivity controls matter. GSK-2033 acts as an antagonist and SR9243 as an inverse agonist, which allows loss-of-function comparisons in the same system.
Synonyms: EXEL04286652; XL-652; BMS-788
BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.