Drug Metabolite

Cat. No.

A29540

CAS No.

1469777-40-9

Lumateperone metabolite 1

Lumateperone metabolite 1 is a key metabolic derivative of Lumateperone, primarily targeting 5-HT2A receptors with high affinity (Ki = 0.54 nM). It exhibits dual action as a partial agonist at presynaptic D2 receptors and antagonist at postsynaptic D2 receptors (Ki = 32 nM), as well as modulation of dopamine D1 receptors. This compound is significant for research applications focused on neuropharmacology and the mechanisms of antipsychotic therapies.

Cat. No.

A40181

CAS No.

257892-31-2

N-Desmethyl rosiglitazone

Synonyms: SB 237216

N-Desmethyl rosiglitazone is a drug metabolite resulting from the demethylation of Rosiglitazone via the cytochrome P450 enzyme system in liver microsomes. This compound exhibits partial agonist activity at the peroxisome proliferator-activated receptor gamma (PPARγ), making it valuable for research into the metabolism and pharmacokinetics of Rosiglitazone. It serves as a useful tool for examining the pharmacological effects and metabolic pathways associated with thiazolidinedione drugs.

Cat. No.

A45857

CAS No.

129722-25-4

Dehydroaripiprazole

Synonyms: OPC-14857; DM-14857

Dehydroaripiprazole is an active metabolite of Aripiprazole, functioning primarily as a partial agonist at dopamine D2 and D3 receptors. This compound also exhibits affinity for serotonin 5-HT1A, 5-HT2A, and 5-HT2B receptors. Its antipsychotic properties are comparable to those of Aripiprazole, making it a valuable tool for research in neuropharmacology and the study of psychiatric disorders.

Cat. No.

A70415

CAS No.

251451-30-6

Zolmitriptan N-Oxide

Zolmitriptan N-Oxide is a metabolite of Zolmitriptan, a selective partial agonist of the 5-HT1B and 5-HT1D serotonin receptors. This compound may play a role in understanding the pharmacodynamics and pharmacokinetics of Zolmitriptan in various biological systems. Research applications include studying the efficacy of migraine therapies and elucidating the metabolic pathways of triptans.