Cl-Necrostatin-1 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1). It effectively blocks TNF-α-induced necroptosis in Jurkat cells lacking FADD, with an EC50 of 180 nM, thereby preventing caspase activation linked to death-domain receptor signaling. Additionally, Cl-Necrostatin-1 has been shown to decrease infarct size in a mouse model of middle cerebral artery occlusion (MCAO), making it a valuable tool for research in cardiovascular and cerebrovascular pathologies.
Cl-Necrostatin-1 is a selective inhibitor of receptor-interacting protein kinase 1 (RIPK1). It effectively blocks TNF-α-induced necroptosis in Jurkat cells lacking FADD, with an EC50 of 180 nM, thereby preventing caspase activation linked to death-domain receptor signaling. Additionally, Cl-Necrostatin-1 has been shown to decrease infarct size in a mouse model of middle cerebral artery occlusion (MCAO), making it a valuable tool for research in cardiovascular and cerebrovascular pathologies.
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