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Microtubule/Tubulin

Microtubule and tubulin inhibitors bind tubulin and either stabilize microtubules or block their assembly. Microtubules are dynamic polymers of α/β-tubulin dimers that build the mitotic spindle and serve as tracks for intracellular transport. Compounds that alter their dynamics arrest cells in mitosis and are standard tools in cell division research. Taxanes such as paclitaxel, docetaxel and cabazitaxel stabilize microtubules, and paclitaxel was shown in 1979 to promote tubulin assembly in vitro. Epothilone B and ixabepilone also stabilize microtubules through the taxane binding region of β-tubulin. The vinca alkaloids vincristine and vinorelbine, colchicine and eribulin act in the opposite direction and suppress polymerization.

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  • PPL agonist-1
    Cat. No.
    A54933
    CAS No.
    3040997-52-9

    PPL agonist-1

    PPL agonist-1 is a selective agonist targeting Periplakin (PPL), known to enhance cyclic adenosine monophosphate (cAMP) levels. This modulation of PPL significantly increases MITF expression, leading to augmented melanin synthesis. Additionally, PPL agonist-1 influences tryptophan metabolism to further stimulate melanin production. Its efficacy positions PPL agonist-1 as a promising candidate for research aimed at investigating potential treatments for vitiligo.

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