Microtubule/Tubulin | Adooq Bioscience

Cat. No.: A32327

CAS No.: 1252802-38-2

NMK-TD-100

NMK-TD-100 is a microtubule modulator that binds to tubulin, effectively inhibiting tubulin polymerization with an IC50 of 17.5 µM. This compound disrupts mitosis and leads to a decrease in mitochondrial membrane potential (MMP). Additionally, NMK-TD-100 demonstrates significant anti-proliferative activity against HeLa cells, with an IC50 of 1.42 µM, causing cell cycle arrest at the G2/M phase and inducing apoptosis. Its applications include studying microtubule dynamics and exploring potential cancer therapies.

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Cat. No.: A54854

CAS No.: 173101-54-7

Iso cephalomannine

Isocephalomannine is a tubulin modulator that exhibits cytotoxic activity against cancer cells. This compound disrupts microtubule dynamics, leading to apoptotic cell death, particularly in breast cancer cells. Isocephalomannine is a valuable tool for research applications focused on cancer biology and therapeutic strategies targeting microtubule stabilization and destabilization.

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Cat. No.: A54887

CAS No.: 49676-35-9

OX01914

OX01914 is a water-soluble utrophin modulator that enhances utrophin protein levels, demonstrating an EC50 value of 20.5 μM. This compound serves as a valuable tool in the study of Duchenne muscular dystrophy (DMD), facilitating research aimed at developing therapeutic strategies for this condition. Its mechanism of action supports investigations into muscle regeneration and the functional recovery of dystrophic muscle tissue.

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Cat. No.: A54890

CAS No.: 3068935-32-7

Utrophin modulator 1

Utrophin modulator 1 is a potent utrophin modulator that upregulates utrophin protein levels, demonstrating an EC50 value of 0.11 μM. This compound is particularly relevant in research focused on Duchenne muscular dystrophy (DMD), offering a valuable tool for studies aimed at exploring therapeutic strategies for this debilitating condition. Its ability to enhance utrophin expression positions it as a promising candidate in the development of targeted treatments.

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Cat. No.: A54892

CAS No.: 404886-32-4

Fosbretabulin tromethamine

Fosbretabulin tromethamine is a tubulin modulator that disrupts microtubule dynamics. It acts as a vascular disrupting agent, primarily targeted for the treatment of anaplastic thyroid carcinoma (ATC) by inducing acute, reversible reductions in tumor blood flow and resulting in central necrosis. This compound is instrumental in researching tumor vasculature and assessing therapeutic strategies aimed at disrupting blood supply to tumors.

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Cat. No.: A54933

CAS No.: 3040997-52-9

PPL agonist-1

PPL agonist-1 is a selective agonist targeting Periplakin (PPL), known to enhance cyclic adenosine monophosphate (cAMP) levels. This modulation of PPL significantly increases MITF expression, leading to augmented melanin synthesis. Additionally, PPL agonist-1 influences tryptophan metabolism to further stimulate melanin production. Its efficacy positions PPL agonist-1 as a promising candidate for research aimed at investigating potential treatments for vitiligo.

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