DC-PRC2in-01 is a potent inhibitor of the EZH2-EED interaction, exhibiting an IC50 of 4.21 μM and a dissociation constant (Kd) of 4.56 μM. This compound disrupts the EZH2-EED complex, leading to degradation of PRC2 core components and a reduction in H3K27me3 levels. Consequently, DC-PRC2in-01 effectively inhibits PRC2-driven proliferation of lymphoma cells and induces cell cycle arrest. It is particularly valuable for studying PRC2-related malignancies, such as Diffuse Large B-cell Lymphoma (DLBCL) and follicular lymphoma (FL).
DC-PRC2in-01 is a potent inhibitor of the EZH2-EED interaction, exhibiting an IC50 of 4.21 μM and a dissociation constant (Kd) of 4.56 μM. This compound disrupts the EZH2-EED complex, leading to degradation of PRC2 core components and a reduction in H3K27me3 levels. Consequently, DC-PRC2in-01 effectively inhibits PRC2-driven proliferation of lymphoma cells and induces cell cycle arrest. It is particularly valuable for studying PRC2-related malignancies, such as Diffuse Large B-cell Lymphoma (DLBCL) and follicular lymphoma (FL).
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
