Dehydroglyasperin D is a selective inhibitor of Aldose Reductase (AR), demonstrating IC50 values of 62.4 μM for rat AR and 176.2 μM for human AR. This compound exhibits significant anti-obesity and antioxidant properties, in addition to its anti-inflammatory effects, which involve the inhibition of COX-2 expression and the MLK3 signaling pathway. Moreover, Dehydroglyasperin D inhibits melanin synthesis, making it relevant for research in metabolic disorders and pigmentation. Isolated from Glycyrrhiza uralensis, this prenylated flavonoid serves as a valuable tool for studying various biological processes.
Dehydroglyasperin D is a selective inhibitor of Aldose Reductase (AR), demonstrating IC50 values of 62.4 μM for rat AR and 176.2 μM for human AR. This compound exhibits significant anti-obesity and antioxidant properties, in addition to its anti-inflammatory effects, which involve the inhibition of COX-2 expression and the MLK3 signaling pathway. Moreover, Dehydroglyasperin D inhibits melanin synthesis, making it relevant for research in metabolic disorders and pigmentation. Isolated from Glycyrrhiza uralensis, this prenylated flavonoid serves as a valuable tool for studying various biological processes.
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