Diclofenac-13C6 is a stable isotope-labeled form of Diclofenac, a potent nonselective anti-inflammatory agent that primarily functions as a cyclooxygenase (COX) inhibitor. It exhibits low nanomolar IC50 values of 4 nM and 1.3 nM for human COX-1 and COX-2, respectively. In addition to its inhibitory effects, Diclofenac promotes apoptosis in neural stem cells by activating the caspase signaling cascade. This reagent is valuable for pharmacokinetic studies and metabolic research involving COX pathways and cellular apoptosis mechanisms.
Diclofenac-13C6 is a stable isotope-labeled form of Diclofenac, a potent nonselective anti-inflammatory agent that primarily functions as a cyclooxygenase (COX) inhibitor. It exhibits low nanomolar IC50 values of 4 nM and 1.3 nM for human COX-1 and COX-2, respectively. In addition to its inhibitory effects, Diclofenac promotes apoptosis in neural stem cells by activating the caspase signaling cascade. This reagent is valuable for pharmacokinetic studies and metabolic research involving COX pathways and cellular apoptosis mechanisms.
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