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DNA Damage

Items 101-150 of 3581

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Product Name
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Product Information
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  1. A19562
    5-Fluorouridine
    5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity.
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  2. A10071
    Amonafide (AS1413)

    Topoisomerase inhibitor

    Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

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  3. A13218
    RGFP966

    HDAC3 inhibitor

    RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
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  4. A17555
    Ciprofloxacin hydrochloride hydrate

    Topoisomerase IV inhibitor

    Ciprofloxacin Hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline, interfering with the bacterial DNA gyrase, inhibiting the DNA synthesis, and preventing bacterial cell growth.
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  5. A10046
    AG14361

    PARP1 inhibitor

    AG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
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  6. A10465
    Idarubicin HCl

    Topoisomerase inhibitor

    Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
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  7. A11161
    Wortmannin

    PI3K inhibitor

    Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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  8. A12665
    PJ 34 hydrochloride

    PARP inhibitor

    PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
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  9. A15106
    Hoechst 33258 trihydrochloride
    Hoechst 33258 trihydrochloride is a cell dye for DNA quantitation.
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  10. A10036
    Cycloheximide (Actidione)

    Protein Synthesis Inhibitor

    Cycloheximide (also known as actidione) is used as an selective antibiotic. It inhibits the protein synthesis (DNA-dependent RNA) of saprobic fungi eukaryotes. by binding with the 80S ribosome, while inactive against dermatophytes and systemic fungi.
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  11. A13059
    Beta-Lapachone

    DNA topoisomerase II inhibitor

    Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
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  12. A10228
    Clofarabine

    DNA/RNA Synthesis inhibitor

    Clofarabine is a second generation purine nucleoside analog with antineoplastic activity
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  13. A12409
    Epirubicin

    Topoisomerase inhibitor

    Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin?€?s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).
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  14. A15902
    SirReal2

    Selective SIRT2 inhibitor

    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
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  15. A10346
    Oxaliplatin (Eloxatin)

    DNA/RNA Synthesis inhibitor

    Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects.
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  16. A16419
    AZD0156

    ATM inhibitor

    AZD0156 is a potent and selective inhibitors of ATM kinase, with potential chemo-/radio-sensitizing and antineoplastic activities.
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  17. A11434
    Gemcitabine

    DNA synthesis inhibitor

    Gemcitabine (LY 188011) is a DNA synthesis inhibitor which inhibits the growth of BxPC-3, Mia Paca-2, PANC-1, PL-45 and AsPC-1 cells with IC50s of 37.6, 42.9, 92.7, 89.3 and 131.4 nM, respectively.
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  18. A11605
    VE-821

    ATM/ATR inhibitor

    VE-821 is a potent and selective inhibitor of protein kinase ATR.
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  19. A14128
    TMP 269

    HDAC inhibitor

    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
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  20. A11037
    AR-42 (HDAC-42)

    HDAC inhibitor

    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
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  21. A10776
    Raltitrexed (Tomudex)

    DNA/RNA Synthesis inhibitor

    Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.
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  22. A10111
    Olaparib (AZD2281)

    PARP inhibitor

    Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
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  23. A16194
    RK-33

    DDX3 inhibitor

    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity.
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  24. A21333
    BOLD-100 (NKP-1339)
    NKP-1339 (IT-139) is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer with limited side effects.
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  25. A12337
    4E2RCat

    eIF4E-eIF4G interaction inhibitor

    4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
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  26. A12374
    VCH-916

    HCV NS5B polymerase inhibitor

    VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
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  27. A12381
    Cambinol

    SIRT1/SIRT2 inhibitor

    Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively.
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  28. A12393
    AZD-2461

    PARP Inhibitor

    AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
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  29. A12406
    Apaziquone
    Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities.
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  30. A12456
    ACY-775

    HDAC6 inhibitor

    ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5?nM.
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  31. A12511
    BRD-6929

    HDAC1/HDAC2 inhibitor

    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927.
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  32. A12516
    KIRA6

    IRE1α RNase kinase inhibitor

    KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC50 of 0.6 ?M. KIRA6 can trigger an apoptotic response.
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  33. A12527
    Inauhzin

    SIRT1 inhibitor

    Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
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  34. A12540
    9-amino-CPT

    Topoisomerase I inhibitor

    9-Aminocamptothecin is a topoisomerase I inhibitor with potent anticancer activity.
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  35. A12556
    Resminostat

    HDAC inhibitor

    Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.
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  36. A12569
    Ametantrone

    topoisomerase II inhibitor

    Ametantrone (AM) is a synthetic 9,10-anthracenedione bearing two (hydroxyethylamino)ethylamino residues at positions 1 and 4 along with other anthraquinones and anthracyclines.
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  37. A12616
    Tasquinimod

    HDAC4 inhibitor

    Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling.
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  38. A12626
    Fosteabine
    Fosteabine is an oral and prodrug analogue of cytarabine which is resistant to deoxycytidine deaminase.
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  39. A12663
    Amrubicin

    Topoisomerase II inhibitor

    Amrubicin is a synthetic anthracycline antibiotic. It inhibits DNA topoisomerase II. Antineoplastic.
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  40. A12668
    Pemetrexed

    DHFR inhibitor

    Pemetrexed is a novel antifolate with multiple targets
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  41. A12691
    Palifosfamide
    Palifosfamide is a synthetic mustard compound with potential antineoplastic activity.
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  42. A12722
    Scriptaid

    HDAC inhibitor

    Scriptaid is an HDAC inhibitor (histone deacetylase).
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  43. A12745
    Apicidin

    HDAC inhibitor

    Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
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  44. A12750
    UPF 1069

    PARP2 inhibitor

    UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
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  45. A12856
    Gimatecan

    topoisomerase I inhibitor

    Gimatecan is an orally bioavailable, semi-synthetic lipophilic analogue of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic and antiangiogenic activities.
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  46. A12890
    Thiostrepton

    natural cyclic oligopeptide antibiotic

    Antibiotic that inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2). Antitumor agent; induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression.
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  47. A12904
    AK-7

    SIRT2 inhibitor

    AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
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  48. A12911
    BRD9757

    HDAC6 inhibitor

    BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.
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  49. A12956
    eIF4A3-IN-1

    eIF4A3 inhibitor

    eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM).
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  50. A12992
    HQL-79
    HQL-79 is a selective inhibitor of hematopoietic prostaglandin D (PGD) synthase, that structurally is a synthetic tetrazole compound originally prepared as a possible antihistamine.
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Items 101-150 of 3581

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  1. Inhibitor 1503items
  2. Agonist 1item
  3. Activator 15items
  4. Modulator 2items
  5. Degrader 1item
  6. Inducer 1item
  7. Substrate 2items
Target
  1. HDAC 3items
  2. HDAC1 4items
  3. HDAC2 4items
  4. HDAC3 4items
  5. HDAC4 3items
  6. HDAC5 2items
  7. HDAC6 5items
  8. HDAC7 1item
  9. HDAC8 4items
  10. HDAC9 2items
  11. HDAC10 2items
  12. HDAC11 1item
  13. HD1 1item
  14. HD2 1item
  15. EGFR/ErbB1/HER1 1item
  16. ErbB2/HER2 1item
  17. GCN 2items
  18. PARP 8items
  19. PARP1 28items
  20. PARP2 22items
  21. PARP3 3items
  22. PARP4 1item
  23. TNKS1/PARP5A 11items
  24. TNKS2/PARP5B 11items
  25. PARP7 1item
  26. PARP10 1item
  27. PARP14 2items