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DNA Damage

Items 101-150 of 3581

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  1. A10407
    Tegafur

    DNA/RNA Synthesis inhibitor

    Tegafur is a chemotherapeutic 5-FU prodrug used in the treatment of cancers. It is a component of tegafur-uracil.
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  2. A11590
    T-705 (Favipiravir)

    viral RNA polymerase inhibitor

    T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo.

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  3. A15215
    PJ34

    PARP inhibitor

    PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
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  4. A19562
    5-Fluorouridine
    5-Fluorouridine is a metabolite of 5-fluorouracil with anticancer activity.
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  5. A10071
    Amonafide (AS1413)

    Topoisomerase inhibitor

    Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.

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  6. A13218
    RGFP966

    HDAC3 inhibitor

    RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.
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  7. A17555
    Ciprofloxacin hydrochloride hydrate

    Topoisomerase IV inhibitor

    Ciprofloxacin Hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline, interfering with the bacterial DNA gyrase, inhibiting the DNA synthesis, and preventing bacterial cell growth.
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  8. A10046
    AG14361

    PARP1 inhibitor

    AG14361 is a potent PARP inhibitor, enhanced TMZ cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
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  9. A10465
    Idarubicin HCl

    Topoisomerase inhibitor

    Idarubicin is an anthracycline antibiotic that is an anti-leukemia agent with higher DNA binding capacity and greater cytotoxicity than daunorubicin.
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  10. A11161
    Wortmannin

    PI3K inhibitor

    Wortmannin is a potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC50 = 2 - 4 nM) which also potently inhibits polo-like kinase 1 (PLK1) (IC50 = 5.8 nM).

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  11. A13239
    Actinomycin D
    Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria.
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  12. A12665
    PJ 34 hydrochloride

    PARP inhibitor

    PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
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  13. A15106
    Hoechst 33258 trihydrochloride
    Hoechst 33258 trihydrochloride is a cell dye for DNA quantitation.
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  14. A13059
    Beta-Lapachone

    DNA topoisomerase II inhibitor

    Beta-Lapachone is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase.
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  15. A10228
    Clofarabine

    DNA/RNA Synthesis inhibitor

    Clofarabine is a second generation purine nucleoside analog with antineoplastic activity
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  16. A12409
    Epirubicin

    Topoisomerase inhibitor

    Epirubicin is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin that exhibits reduced cardiotoxicity. Epirubicin?€?s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).
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  17. A15902
    SirReal2

    Selective SIRT2 inhibitor

    SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
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  18. A10346
    Oxaliplatin (Eloxatin)

    DNA/RNA Synthesis inhibitor

    Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. In vivo studies showed that Oxaliplatin has anti-tumor activity against colon carcinoma through its (non-targeted) cytotoxic effects.
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  19. A11605
    VE-821

    ATM/ATR inhibitor

    VE-821 is a potent and selective inhibitor of protein kinase ATR.
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  20. A14128
    TMP 269

    HDAC inhibitor

    TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.
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  21. A11037
    AR-42 (HDAC-42)

    HDAC inhibitor

    AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
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  22. A10776
    Raltitrexed (Tomudex)

    DNA/RNA Synthesis inhibitor

    Raltitrexed (Tomudex) is an inhibitor of thymidylate synthase and also is one of the strongest antimetabolites in use.
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  23. A10111
    Olaparib (AZD2281)

    PARP inhibitor

    Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
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  24. A11491
    Mitomycin C

    DNA synthesis inhibitor

    Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
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  25. A16194
    RK-33

    DDX3 inhibitor

    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity.
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  26. A21333
    BOLD-100 (NKP-1339)
    NKP-1339 (IT-139) is the first-in-class ruthenium-based anticancer drug in clinical development against solid cancer with limited side effects.
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  27. A11120
    Abacavir sulfate

    Transcriptase inhibitor

    Abacavir sulfate is a nucleoside analog reverse transcriptase inhibitor (NRTI); guanosine analog used to treat HIV and AIDS.
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  28. A11147
    CCT239065

    DNA, RNA Synthesis Inhibitor

    CCT239065 is a mutant protein kinase inhibitor that inhibits signaling downstream of V600EBRAF in cancer cells, blocking DNA synthesis, and inhibiting proliferation.
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  29. A11152
    PCI-34051

    HDAC inhibitor

    PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.
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  30. A11179
    NSC-207895 (XI-006)

    MDMX Inhibitor

    NSC207895 is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation.

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  31. A11231
    Exatecan

    Topoisomerase I inhibitor

    Exatecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death.
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  32. A11335
    Balapiravir (R1626)

    Polymerase inhibitor

    Balapiravir (R1626, RG1626) is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase (R1479, RG1479).
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  33. A11355
    M344

    HDAC inhibitor

    M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation.
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  34. A11361
    BG45

    HDAC inhibitor

    BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).
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  35. A11454
    TC-E 5001

    TNKS inhibitor

    TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.
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  36. A11510
    Nesbuvir

    HCV Polymerase Inhibitor

    HCV-796 is a selectively inhibitor of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase.
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  37. A11522
    Pralatrexate

    DHFR inhibitor

    Pralatrexate is an antifolate (a folate analogue metabolic inhibitor) designed to accumulate preferentially in cancer cells.
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  38. A11530
    PSI-6206

    HCV RNA polymerase inhibitor

    PSI-6206 is the deaminated derivative of PSI-6130, which is a potent inhibitor of hepatitis C virus (HCV) replication in the subgenomic HCV reolicon system.
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  39. A11539
    Mericitabine

    HCV NS5B polymerase inhibitor

    Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
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  40. A11574
    Silvestrol

    eIF4A inhibitor

    Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from the fruits and twigs of Aglaia foveolata. Silvestrol induces autophagy and caspase-mediated apoptosis.
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  41. A11575
    Silvestrol aglycone
    Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity.
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  42. A11577
    SRT3190

    SIRT1 activator

    SRT3190 is a potent CXCR2 ligand.
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  43. A11583
    Tegobuvir (GS-9190)

    NS5B polymerase inhibitor

    Tegobuvir (GS-9190 is a non-nucleoside NS5B polymerase inhibitor.
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  44. A11596
    Triptolide (PG490)
    Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
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  45. A11626
    Levoleucovorin Calcium
    Levoleucovorin calcium is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid.
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  46. A11628
    Procarbazine Hydrochloride
    Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
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  47. A11629
    Nedaplatin
    Nedaplatin (NSC 375101D) is a derivative of cisplatin and DNA damage agent.
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  48. A11635
    Cyclophosphamide monohydrate
    Cyclophosphamide monohydrate is an alkylating, cytotoxic agent experimentally shown to crosslink DNA, causing strand breakage and inducing mutations.
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  49. A11658
    Balofloxacin

    Topoisomerase inhibitor

    Balofloxacin is a quinolone antibiotic. The bactericidal action of Balofloxacin results from interference with the enqyme DNA gyrase which is needed for the synthesis of bacterial DNA. Balofloxacin is efficacious against Gram-negative bacteria. It also has enhanced activity against Gram positive bacteria, including MRSA and Streptococcus pneumoniae.
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  50. A11659
    Sarafloxacin HCl

    Topoisomerase inhibitor

    Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase).
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Items 101-150 of 3581

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  1. Inhibitor 1503items
  2. Agonist 1item
  3. Activator 15items
  4. Modulator 2items
  5. Degrader 1item
  6. Inducer 1item
  7. Substrate 2items
Target
  1. HDAC 3items
  2. HDAC1 4items
  3. HDAC2 4items
  4. HDAC3 4items
  5. HDAC4 3items
  6. HDAC5 2items
  7. HDAC6 5items
  8. HDAC7 1item
  9. HDAC8 4items
  10. HDAC9 2items
  11. HDAC10 2items
  12. HDAC11 1item
  13. HD1 1item
  14. HD2 1item
  15. EGFR/ErbB1/HER1 1item
  16. ErbB2/HER2 1item
  17. GCN 2items
  18. PARP 8items
  19. PARP1 28items
  20. PARP2 22items
  21. PARP3 3items
  22. PARP4 1item
  23. TNKS1/PARP5A 11items
  24. TNKS2/PARP5B 11items
  25. PARP7 1item
  26. PARP10 1item
  27. PARP14 2items