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ATM/ATR

ATM and ATR inhibitors act on ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases. The ATM gene was cloned in 1995 and encodes a protein similar to phosphatidylinositol 3-kinase (PI3K). ATR was cloned in 1996 as a candidate human cell cycle checkpoint protein. ATM responds mainly to DNA double-strand breaks, whereas ATR is activated by stalled replication forks. KU-55933, described in 2004 as a specific ATM inhibitor, is joined by KU-60019 and AZD0156. Ceralasertib, VE-821 and BAY-1895344 inhibit ATR and are used to study replication stress. Broader inhibitors of PI3K-related kinases, such as wortmannin, also appear in this list. Inhibitors of DNA-dependent protein kinase are listed in the sibling category DNA-PK.

1 Item

  • ATR kinase substrate peptide
    Cat. No.
    A54077
    CAS No.
    1232497-16-3

    ATR kinase substrate peptide

    ATR kinase substrate peptide (ASELPASQPQPFSAKKK) functions as a specific substrate for ATR protein kinase, facilitating the detection of ATR kinase activity in biological research. This peptide is instrumental in studying cellular responses to DNA damage and the associated signaling pathways. It plays a critical role in validating ATR kinase activity and exploring its implications in cancer biology and therapeutic development.

    In stock View Details
    1 mg
    $40.00
    5 mg
    $105.00
    All 3 sizes

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