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DNA/RNA Synthesis

DNA and RNA synthesis inhibitors interfere with nucleic acid replication or transcription by distinct mechanisms. Platinum compounds such as cisplatin, carboplatin and oxaliplatin form DNA adducts, mainly crosslinks between adjacent guanines on the same strand. These adducts block DNA replication and transcription and trigger DNA damage responses. Mitomycin C also crosslinks DNA, but only after reductive activation inside cells. Gemcitabine, a deoxycytidine analog, is incorporated into DNA as its triphosphate and halts chain elongation. CX-5461 acts on transcription, inhibiting synthesis of ribosomal RNA by RNA polymerase I. The protein synthesis inhibitor cycloheximide, which blocks translation elongation on eukaryotic ribosomes, is listed here as well.

3 Items

  • 5-Fluoro-2′-deoxy-UTP
    Cat. No.
    A37891
    CAS No.
    2710-64-7

    5-Fluoro-2′-deoxy-UTP

    5-Fluoro-2′-deoxy-UTP is a nucleotide analog primarily utilized as a substrate in DNA synthesis. This compound incorporates into DNA strands, allowing researchers to study nucleotide incorporation and the effects of fluorinated nucleotides on replication and genetic stability. It is widely used in molecular biology applications, including the synthesis of modified oligonucleotides and in various labeling techniques for DNA analysis.

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    5 mg
    $290.00
    10 mg
    $475.00
    All 5 sizes
  • pppApG
    Cat. No.
    A38407
    CAS No.
    68892-47-7

    pppApG

    pppApG is a pivotal nucleotide involved in the synthesis of both viral RNA (vRNA) and complementary RNA (cRNA). This compound serves as a critical starting substrate in the assembly of viral genomes, making it essential for influenza virus research and related studies. Its application supports investigations into viral replication mechanisms and the development of antiviral strategies.

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    Out of stock

    All 3 sizes
  • 5-Fluoro-2′-deoxy-UTP sodium
    Cat. No.
    A38577
    CAS No.
    1630828-71-5

    5-Fluoro-2′-deoxy-UTP sodium

    5-Fluoro-2′-deoxy-UTP sodium serves as a nucleotide substrate in DNA synthesis. It incorporates into DNA strands during replication and transcription, providing a means to study nucleic acid processes and investigate mutations. This reagent is essential for applications such as polymerase chain reactions and other molecular biology techniques that require modified nucleotides.

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    Out of stock

    All 3 sizes

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