- Cat. No.
- A15894
6-Thio-dG
6-thio-dG is a nucleoside analog and telomerase substrate.
In stock
View Details
Search by product name, CAS, target or catalog number. Press Down Arrow to reach product suggestions, Tab to move between links, and Escape to close suggestions.
Telomerase inhibitors and activators act on telomerase, the reverse transcriptase that extends telomeres. Telomerase activity was first found in 1985 in Tetrahymena extracts, as a terminal transferase that adds telomeric repeats. The human enzyme pairs telomerase reverse transcriptase (TERT) with an RNA template. A 1994 study detected telomerase activity in most immortal cell lines and tumors but rarely in normal somatic tissues. BIBR 1532 inhibits the enzyme directly, while Braco-19, RHPS4 and TMPyP4 tosylate stabilize telomeric G-quadruplex DNA. 6-Thio-dG is a nucleoside that telomerase incorporates into telomeres, and epithalon is listed as an activator. The set also includes the topoisomerase inhibitors amsacrine and GENZ-644282.
6-thio-dG is a nucleoside analog and telomerase substrate.