Biological Activity
Dolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
Targets
HIV integrase | ||||
2.7 nM |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.66 mL | 113.29 mL | 226.57 mL |
0.5 mM | 4.53 mL | 22.66 mL | 45.31 mL |
1 mM | 2.27 mL | 11.33 mL | 22.66 mL |
5 mM | 0.45 mL | 2.27 mL | 4.53 mL |
*The above data is based on the productmolecular weight 441.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A16162 |
---|---|
Actions | Inhibitor |
M. Wt | 441.36 |
Formula | C20H18F2N3NaO5 |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1051375-19-9 |
Synonyms | DTG, GSK1349572 |
SMILES | CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+] |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy Dolutegravir Sodium | Dolutegravir Sodium Supplier | purchase | cost | manufacturer | order | distributor | buy 1051375-19-9| 1051375-19-9 Supplier | purchase 1051375-19-9 | 1051375-19-9 cost | 1051375-19-9 manufacturer | order 1051375-19-9 | 1051375-19-9 distributor