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$0.00 Biological Activity
Dolutegravir sodium is a HIV integrase inhibitor(IC50= 2.7 nM), modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
Targets
| HIV integrase | ||||
| 2.7 nM |
| In vitro | DMSO | 0.18 mg/mL (0.41 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.66 mL | 113.29 mL | 226.57 mL |
| 0.5 mM | 4.53 mL | 22.66 mL | 45.31 mL |
| 1 mM | 2.27 mL | 11.33 mL | 22.66 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.53 mL |
*The above data is based on the productmolecular weight 441.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16162 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1051375-19-9 |
| Formula | C20H18F2N3NaO5 |
| M. Wt | 441.36 |
| Purity | >98% |
| Synonyms | DTG, GSK1349572 |
| SMILES | CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+] |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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