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Orphan Nuclear Receptor

Orphan nuclear receptor ligands act on nuclear receptors cloned before a natural ligand was known. The term dates from 1988, when estrogen-related receptors were identified by sequence similarity to the estrogen receptor. Many further superfamily members were found this way, as a 1995 review of the second decade of nuclear receptor research describes. Liver receptor homolog 1 (LRH-1, NR5A2) regulates development, metabolism and steroidogenesis. ML-180 is an LRH-1 inverse agonist, LRH-1 agonist-2 activates the receptor, and RJW100 activates LRH-1 together with steroidogenic factor 1 (SF-1). MI-883 activates and CINPA1 inhibits the constitutive androstane receptor (CAR). The set is mixed and also lists compounds for unrelated targets, such as splicing factor 3B subunit 1 (SF3B1).

2 Items

  • Nurr1 inverse agonist-1
    Cat. No.
    A85340
    CAS No.
    2758673-07-1

    Nurr1 inverse agonist-1

    Nurr1 inverse agonist-1 is a selective inverse agonist targeting the neuroprotective transcription factor Nurr1. This compound modulates Nurr1 activity, inhibiting its transcriptional functions, and is crucial for studying its role in neurodegenerative diseases and neuroprotection mechanisms. It serves as an essential tool for researchers investigating the effects of Nurr1 inhibition on neuronal cell survival and differentiation.

    In stock View Details
    2 mg
    $120.00
    5 mg
    $215.00
    All 5 sizes
  • ML179
    Cat. No.
    B18175
    CAS No.
    1883548-87-5

    ML179

    ML179 serves as an inverse agonist for Liver Receptor Homologue-1 (LRH-1/NR5A2), exhibiting an IC50 value of 320 nM. This compound demonstrates notable anti-proliferative effects, particularly in MDA-MB-231 breast cancer cells. ML179 is a valuable tool for investigating the mechanisms underlying estrogen receptor-negative breast cancer and has potential applications in related therapeutic research.

    In stock View Details
    1 mg
    $25.00
    5 mg
    $60.00
    All 7 sizes

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