MicroRNA

Cat. No.

A25847

CAS No.

3076057-63-8

FHND5032

FHND5032 is an orally active miR-124 inducer that enhances miR-124 expression in macrophages. Its mechanism involves the inhibition of the PIK3R2/PI3K/Akt signaling pathway, leading to disrupted inflammatory signaling and improved macrophage reprogramming. FHND5032 has demonstrated efficacy in alleviating colitis and reducing the inflammatory burden in models of ulcerative colitis, making it a valuable reagent for research focused on inflammatory bowel diseases.

Cat. No.

A30825

CAS No.

73543-67-6

9S-HODE

Synonyms: Alpha-dimorphecolic acid

9S-HODE is a potent modulator of miR-361-3p, primarily derived from Linoleic acid. This compound has been shown to reduce cancer cell viability and induce apoptosis in various cancer cell lines. It presents valuable applications in the study of acute myeloid leukemia and may provide insights into therapeutic strategies targeting miRNA regulation in cancer.

Cat. No.

A57840

CAS No.

73694-15-2

Rubone

Rubone is a chalcone analog that functions as a modulator of miR-34a, promoting its expression in a p53-dependent manner. This modulation results in the downregulation of key oncogenic targets, including Bcl-2 and Cyclin D1, thereby inhibiting growth in hepatocellular carcinoma (HCC) models. Additionally, Rubone enhances the efficacy of Paclitaxel in resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets, making it a valuable tool for cancer research applications.