TET Protein Modulators | Adooq Bioscience

Cat. No.: A24343

CAS No.: 2436747-44-1

Bobcat339 hydrochloride

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET (ten-eleven translocation) enzymes, with IC₅₀ values of 33 μM for TET1 and 73 μM for TET2. By inhibiting TET-mediated DNA demethylation, it modulates epigenetic regulation and gene transcription. Bobcat339 hydrochloride is a valuable tool in epigenetics research and serves as a potential lead compound for developing therapeutics targeting DNA methylation-related diseases.

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Cat. No.: A24362

CAS No.: 1445703-64-9

TFMB-(S)-2-HG

TFMB-(S)-2-HG is a potent inhibitor of TET2 and EglN prolyl hydroxylases. It downregulates Wnt3a and intranuclear β-catenin protein expression, and inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG shows potential for research in acute myeloid leukemia (AML).

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Cat. No.: A36494

CAS No.: 116409-29-1

NSC-370284

NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1), targeting the enzymatic conversion of cytosine to 5-hydroxymethylcytosine (5hmC). This compound effectively reduces TET1 expression levels by interacting with STAT3/5 signaling pathways. NSC-370284 is valuable for research in epigenetics and may be utilized to explore the role of TET1 in various biological processes and disease states.

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5 mg

$30.00

10 mg

$60.00

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Cat. No.: A57691

CAS No.: 2280037-51-4

Bobcat339

Bobcat339 is a selective inhibitor of the TET enzymes, exhibiting IC50 values of 33 μM and 73 μM for TET1 and TET2, respectively. This compound is significant for studies in epigenetics, including the modulation of DNA methylation and gene expression. Bobcat339 serves as a valuable tool for researchers exploring the therapeutic potential of targeting TET enzymes in various biological contexts.

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5 mg

$40.00

10 mg

$65.00

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Cat. No.: A57843

CAS No.: 1451750-73-4

TETi76

TETi76 is a potent inhibitor of TET family enzymes, demonstrating IC50 values of 1.5 μM for TET1, 9.4 μM for TET2, and 8.8 μM for TET3. By competitively binding to the active site of these enzymes, TETi76 effectively decreases cytosine hydroxymethylation and inhibits the clonal growth of TET2 mutant cells both in vitro and in vivo, while sparing normal hematopoietic precursor cells. This selective activity makes TETi76 a valuable tool for investigating leukemia and studying TET-related pathways in cancer research.

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5 mg

$130.00

10 mg

$200.00

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Cat. No.: A57844

CAS No.: 73768-68-0

NSC-311068

NSC-311068 is a potent inhibitor of TET1, targeting the enzyme's transcriptional activity and its role in modifying 5-hydroxymethylcytosine (5hmC). This compound effectively reduces TET1 expression levels and attenuates global 5hmC levels. NSC-311068 demonstrates significant cytotoxicity in acute myeloid leukemia (AML) cells characterized by elevated TET1 expression, making it a valuable tool for studying TET1-related pathways and potential therapeutic approaches in AML.

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5 mg

$65.00

10 mg

$105.00

All 5 sizes