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- Baihong Guo, .et al. Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice, Neurobiol Aging, 2020, Sep 12;96:223-232 PMID: 33039900
Biological Activity
Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.34 mL | 101.69 mL | 203.38 mL |
| 0.5 mM | 4.07 mL | 20.34 mL | 40.68 mL |
| 1 mM | 2.03 mL | 10.17 mL | 20.34 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.07 mL |
*The above data is based on the productmolecular weight 491.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11412 |
|---|---|
| CAS No. | 189453-10-9 |
| Formula | C27H41NO5S |
| M. Wt | 491.68 |
| Purity | >98% |
| Synonyms | Desoxyepothilone B, KOS 862 |
| SMILES | C[[email protected]]1CCC/C(=C\C[[email protected]](OC(=O)C[[email protected]@H](C(C(=O)[[email protected]@H]([[email protected]]1O)C)(C)C)O)/C(=C/C2=CSC(=N2)C)/C)/C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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