GDC-0570

Name: GDC-0570
Brand: Adooq Bioscience
SKU: A40893
Rating: 5 (288 reviews)

Catalog No.: A40893

Pan-PIM Inhibitor

GDC-0570 is a potent and selective pan-PIM inhibitor designed for oral administration. It exhibits pronounced antitumor activity and has shown synergistic effects when combined with Sotorasib in models of acquired KRAS-resistant non-small cell lung cancer (NSCLC). This compound serves as a valuable tool for investigating the role of PIM kinases in cancer biology and therapeutic resistance.

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Biological Activity

Description	GDC-0570 is a potent and selective pan-PIM inhibitor designed for oral administration. It exhibits pronounced antitumor activity and has shown synergistic effects when combined with Sotorasib in models of acquired KRAS-resistant non-small cell lung cancer (NSCLC). This compound serves as a valuable tool for investigating the role of PIM kinases in cancer biology and therapeutic resistance.

Product Information

Catalog Num	A40893
Formula	C20H20F3N5O2S
Molecular Weight	451.47
CAS Number	1586041-58-8
SMILES	O=C(C1=CSC(C2=C(C=CC=C2F)F)=N1)NC3=C([C@@H]4CC[C@H]([C@@H](CO4)F)N)N(N=C3)C
Synonyms	NB004

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