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$0.00 Biological Activity
GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.
Targets
| M351T | T315I | E255V | c-Abl | G250E |
| <5 nM | 61 nM | 122 nM | 133 nM | 136 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.26 mL | 91.32 mL | 182.64 mL |
| 0.5 mM | 3.65 mL | 18.26 mL | 36.53 mL |
| 1 mM | 1.83 mL | 9.13 mL | 18.26 mL |
| 5 mM | 0.37 mL | 1.83 mL | 3.65 mL |
*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15887 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 547.53 |
| Formula | C28H24F3N7O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 839706-07-9 |
| Synonyms | GNF7, GNF 7 |
| SMILES | O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5 |
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