GNF-7

Catalog No.: A15887

Bcr-Abl inhibitor

GNF-7

GNF-7 Chemical Structure

CAS NO. 839706-07-9

GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$200.00
25 mg
$400.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.
Targets
M351T T315I E255V c-Abl G250E
<5 nM61 nM122 nM133 nM136 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.26 mL 91.32 mL 182.64 mL
0.5 mM 3.65 mL 18.26 mL 36.53 mL
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15887
Actions Inhibitor
M. Wt 547.53
Formula C28H24F3N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 839706-07-9
Synonyms GNF7, GNF 7
SMILES O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5

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