GNF-7

Catalog No.: A15887

Bcr-Abl inhibitor

GNF-7

GNF-7 Chemical Structure

CAS NO. 839706-07-9

GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.

Availability: In stock

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5 mg

Regular Price: $100.00

Special Price $80.00

10 mg

Regular Price: $165.00

Special Price $132.00

25 mg

Regular Price: $325.00

Special Price $260.00

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Biological Activity

GNF-7 is a potent type-II kinase Bcr-Abl inhibitor with IC50 of <5 nM, 61 nM, 122 nM, 136 nM, and 133 nM for M351T, T315I, E255 V, G250E, and c-Abl, respectively.
Targets
M351T T315I E255V c-Abl G250E
<5 nM61 nM122 nM133 nM136 nM
In vitro DMSO 17 mg/mL (31.04 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.26 mL 91.32 mL 182.64 mL
0.5 mM 3.65 mL 18.26 mL 36.53 mL
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL

*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15887
Actions Inhibitor
CAS No. 839706-07-9
Formula C28H24F3N7O2
M. Wt 547.53
Purity >98%
Synonyms GNF7, GNF 7
SMILES O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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