GSK-340 is a potent BET inhibitor that exhibits high affinity and selectivity for the bromodomain BD2 of BRD4, with a pIC50 value of 7.2. This compound effectively inhibits the release of MCP-1 in lipopolysaccharide-treated PBMCs and whole blood, demonstrating pIC50 values of 7.4 and 6.0, respectively. GSK-340's immunomodulatory properties make it a valuable tool for research applications in inflammation and cancer biology.
GSK-340 is a potent BET inhibitor that exhibits high affinity and selectivity for the bromodomain BD2 of BRD4, with a pIC50 value of 7.2. This compound effectively inhibits the release of MCP-1 in lipopolysaccharide-treated PBMCs and whole blood, demonstrating pIC50 values of 7.4 and 6.0, respectively. GSK-340's immunomodulatory properties make it a valuable tool for research applications in inflammation and cancer biology.
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