DW34 is a pan-BRD4-D1 biased inhibitor with concurrent inhibitory activity against BRD4-D2. It demonstrates potent biological activity with an EC50 of 0.14 μM, making it effective in modulating BRD4 pathways. DW34 significantly mitigates liver inflammation induced by lipopolysaccharide (LPS) and acetaminophen (APAP), primarily by reducing chemokine expression and cellular necrosis. This compound is suitable for research applications focused on inflammatory diseases and BRD4-related pathways.
DW34 is a pan-BRD4-D1 biased inhibitor with concurrent inhibitory activity against BRD4-D2. It demonstrates potent biological activity with an EC50 of 0.14 μM, making it effective in modulating BRD4 pathways. DW34 significantly mitigates liver inflammation induced by lipopolysaccharide (LPS) and acetaminophen (APAP), primarily by reducing chemokine expression and cellular necrosis. This compound is suitable for research applications focused on inflammatory diseases and BRD4-related pathways.
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